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Table 1 Gene expression of notable corticosteroid sensitive genes

From: Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle

Gene symbol

Gene Name

FP

TNFα

FP + TNFα

IFNγ

FP + IFNγ

TNFα/IFNγ

FP + TNFα/IFNγ

Log2 Fold Change

FDR

Log2 Fold Change

FDR

Log2 Fold Change

FDR

Log2 Fold Change

FDR

Log2 Fold Change

FDR

Log2 Fold Change

FDR

Log2 Fold Change

FDR

ALDH1L1

aldehyde dehydrogenase 1 family member L1

8.76

0.0000

-1.53

0.6620

2.02

0.2446

2.35

0.3112

7.14

0.0000

− 3.74

0.2402

1.20

0.4478

ALOX15B

arachidonate 15-lipoxygenase type B

8.55

0.0000

1.89

0.4977

8.02

0.0016

3.82

0.1974

7.37

0.0001

7.31

0.0006

11.37

0.0000

FKBP5

FKBP prolyl isomerase 5

5.70

0.0002

0.004

0.9944

4.73

0.0014

2.52

0.0387

6.23

0.0001

2.12

0.0020

3.65

0.0000

IL6

interleukin 6

− 2.54

0.0042

6.39

0.0007

4.02

0.0062

1.84

0.0573

− 1.46

0.0314

4.67

0.0006

1.69

0.0752

KLF15

Kruppel like factor 15

3.76

0.0017

− 1.43

0.0165

2.17

0.045

− 0.40

0.5341

2.58

0.0014

− 3.96

0.0021

− 3.96

0.0021

MMP1

matrix metallopeptidase 1

− 4.06

0.0002

3.58

0.0185

− 2.46

0.0148

− 0.29

0.7233

− 2.87

0.0003

4.24

0.0000

− 0.63

0.3018

PER1

period circadian regulator 1

2.83

0.0002

0.76

0.0689

2.49

0.0075

0.25

0.3944

2.46

0.0006

0.8007

0.0308

2.65

0.0005

PTGS2

prostaglandin-endoperoxide synthase 2

− 2.73

0.0285

3.19

0.0025

− 1.50

0.2433

1.78

0.0004

-0.52

0.4137

5.22

0.0002

1.92

0.0044

TNFSF15

TNF superfamily member 15

− 2.90

0.0036

5.19

0.0149

1.39

0.290

0.25

0.8182

-2.20

0.1297

5.56

0.0008

2.3002

0.0327

ZBTB16

zinc finger and BTB domain containing 16

9.80

0.0002

− 0.68

0.6542

9.54

0.0032

2.29

0.5185

9.39

0.0000

0.04

0.9606

9.01

0.0002