Fig. 1

TNFα/IFNγ augments chemokine secretion that is insensitive to corticosteroids. A Cells were treated for 3, 6, 12, or 24 h. CCL5 and CXCL10 secretion are further increased by TNFα/IFNγ. B In contrast to TNFα or IFNγ alone, TNFα/IFNγ-induced CCL5 and CXCL10 secretion are insensitive to fluticasone propionate (FP) treatment. C JAK inhibition significantly reduces CCL5 and CXCL10 secretion. Data are presented as means ± SE, n = 3–5 individual ASM samples. *p < 0.05, significant difference from control; ^#p < 0.05, significant difference from TNFα alone; ^$p < 0.05, significant effect of FP or JAK inhibitor I