MAIT cell counts are associated with the risk of hospitalization in COPD

Respiratory Research

Table 2 Results of multi-variable logistic regression analyses with hospitalizations as dependent variable

Independent variable	Regression coefficient	Lower CL 95%	Upper CL 95%	p-value
MAIT cells (% of live CD3 +)	− 0.958	− 1.990	0.074	0.069
CD8 T cells (% of live CD3 +)	0.042	− 0.008	0.092	0.097
CD4 T cells (% of live CD3 +)	− 0.035	− 0.079	0.008	0.113
MAIT cell count (× 10⁶/L)	− 0.074	− 0.148	0.000	0.049
CD8 T cell count (× 10⁶/L)	0.001	− 0.001	0.003	0.562
CD4 T cell count (× 10⁶/L)	− 0.001	− 0.003	0.000	0.114
CD38 + (% of MAIT cells)	0.212	0.068	0.356	0.004
CD38 + (% of CD8 T cells)	− 0.008	− 0.092	0.075	0.844
LAG-3 + (% of MAIT cells)	0.639	0.255	1.022	0.001
LAG-3 + (% of CD8 T cells)	1.013	0.155	1.871	0.021

Multi-variable logistic regression analysis with hospitalizations (any vs none) as dependent variable, and FEV₁ (% predicted), GOLD 2017 group (A–D) and quantity or activation of MAIT cells or classical T cells as independent variables. The MAIT- and T-cell related variables were entered into the model each separately. N = 61 in all
CL confidence level, FEV₁ forced expiratory volume in 1 s, GOLD Global Initiative for Chronic Obstructive Lung Disease, LAG-3 lymphocyte-activation gene 3, MAIT mucosal-associated invariant T

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