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Fig. 5 | Respiratory Research

Fig. 5

From: NecroX-5 ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3-mediated epithelial–mesenchymal transition

Fig. 5

NecroX-5 inhibited EMT process depending on NLRP3 activation in pulmonary epithelial cells exposed to BLM. A α-SMA mRNA expression expression in MLE-12 cells. B Vimentin mRNA expression in MLE-12 cells. C Cytokeratin-8 mRNA expression in MLE-12 cells. D E-cadherin mRNA expression in MLE-12 cells. E α-SMA mRNA expression expression in BEAS-2B cells. F Vimentin mRNA expression in BEAS-2B cells. G Cytokeratin-8 mRNA expression in BEAS-2B cells. H E-cadherin mRNA expression in BEAS-2B cells. I The expression of epithelial and mesenchymal markers in MLE-12 cells was confirmed by immunostaining. J The expression of epithelial and mesenchymal markers in BEAS-2B cells was confirmed by immunostaining. K The morphology of MLE-12 cells. L The morphology of BEAS-2B cells. *P < 0.05, vs. controls; &P < 0.05 vs. BLM

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Respiratory Research

ISSN: 1465-993X

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