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Fig. 4 | Respiratory Research

Fig. 4

From: NecroX-5 ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3-mediated epithelial–mesenchymal transition

Fig. 4

NecroX-5 inhibited the TGF-β1/Smad2/3 pathway depending on NLRP3 activation in pulmonary epithelial cells exposed to BLM. A NLRP3 mRNA expression in MLE-12 cells. B ASC mRNA expression in MLE-12 cells. C Caspase-1 mRNA expression in MLE-12 cells. D The expression of cleaved caspase 1 in MLE-12 cells. E NLRP3 mRNA expression in BEAS-2B cells. F ASC mRNA expression in BEAS-2B cells. G Caspase-1 mRNA expression in BEAS-2B cells. H The expression of cleaved caspase 1 in BEAS-2B cells. I The levels of TGF-β1 in MLE-12 cells. J Protein expression of phospho (p-)Smad2/3 in MLE-12 cells. K Protein expression of Slug in MLE-12 cells. L The levels of TGF-β1 in BEAS-2B cells. M Protein expression of phospho (p-)Smad2/3 in BEAS-2B cells. N Protein expression of Slug in BEAS-2B cells. *P < 0.05, vs. controls; &P < 0.05 vs. BLM

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Respiratory Research

ISSN: 1465-993X

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