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Fig. 2 | Respiratory Research

Fig. 2

From: Roles of airway basal stem cells in lung homeostasis and regenerative medicine

Fig. 2

Basal Stem Cells (BSCs) Take Centre Stage in Airway Regeneration. A Table of cell types found in the proximal airways. B The conducting airway surface and submucosal glands are shown. BSCs in the airway pseudostratified epithelium function as the primary progenitors and could differentiate into virtually every airway epithelium cell population. Sox2 is required for BSC self-renewal. Notch signaling is crucial for the differentiation of BSCs and suppresses ciliated cell differentiation. In the setting of marked BSC ablation, the overexpression of Yes-associated protein 1 (Yap1) transiently stimulates secretory cell de-differentiation and partially gives rise to BSCs. Solid black arrows represent homeostatic cell fates. Dotted black arrows represent reparative strategies only activated after injury

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