| |
Baseline (Visit 1)
|
Three months (Visit 3)
|
One year (Visit 4)
|
One year and a half (Visit 5)
|
Two years (Visit 6)
|
Main effect of time
|
|---|
|
Weight (Kg)
|
N
|
66
| |
45
| |
12
| |
|
Mean (SD)
|
82.5 (16)
| |
83 (13.1)
| |
82.3 (10.6)
| |
|
Range
|
46–129
| |
54–112
| |
71–100
| |
|
Median (IQR)
|
83 (17.6)
| |
83 (18)
| |
79.5 (20)
| |
|
Estimated mean (95% CI)*
|
82.5 (78.6; 86.4)
| |
80.9 (77.2; 84.6)
| |
78.6 (74.5; 81.7)
|
p = 0.0110
|
|
BMI (Kg/m2)
|
N
|
66
| |
45
| |
12
| |
|
Mean (SD)
|
28.6 (4.4)
| |
28.5 (4)
| |
27.3 (3.3)
| |
|
Range
|
19.8–40.4
| |
21–37.8
| |
20.8–32.4
| |
|
Median (IQR)
|
28.1 (5.9)
| |
27.6 (6.4)
| |
27.1 (3.2)
| |
|
Estimated mean (95% CI)*
|
28.6 (27.5; 29.6)
| |
28.0 (27; 29)
| |
27.1 (26; 28.3)
|
p = 0.0061
|
|
BMI category
|
N
|
66
| |
45
| |
12
| |
|
Underweight n (%)
|
0
| |
0
| |
0
| |
|
Normal n (%)
|
13 (9.7)
| |
9 (20.0)
| |
2 (16.7)
| |
|
Overweight n (%)
|
27 (40.9)
| |
19 (42.2)
| |
8 (66.7)
| |
|
Obese n (%)
|
26 (39.4)
| |
17 (37.8)
| |
2 (16.7)
| |
|
Main effect of time*
| |
p = 0.0992
|
|
Smoking status#
|
N
|
66
| | |
|
Never n (%)
|
14 (21.2)
| | |
|
Former n (%)
|
52 (78.8)
| | |
|
Oxygen use#
|
N
|
66
| |
46
| |
13
| |
|
Yes n (%)
|
1 (1.5)
| |
7 (15.2)
| |
2 (15.4)
| |
|
Continuous use
|
1 (100)
| |
5 (83.3)
| |
2 (100)
| |
|
Exercise and sleep
|
0
| |
1 (16.7)
| |
0
| |
|
Gastro oesophageal reflux#
|
N
|
66
| | |
|
Yes n (%)
|
9 (13.6)
| | |
|
DLco % predicted
|
N
|
65
|
56
|
44
|
21
|
11
| |
|
Mean (SD)
|
56.9 (15.7)
|
57.8 (15)
|
55.1 (15.4)
|
54.2 (17.4)
|
58.5 (17.6)
| |
|
Range
|
24–111
|
21–103
|
23–99
|
25–102
|
42–98
| |
|
Median (IQR)
|
57 (18)
|
56.5 (13)
|
56 (17)
|
51 (19)
|
51 (22)
| |
|
Estimated mean (95% CI)*
|
56.9 (53; 60.7)
|
56.1(52.3;59.8)
|
53.2 (49.1; 57.3)
|
50.9 (46.3; 55.5)
|
49 (44.4; 53.7)
|
p < 0.0001
|
|
FVC % predicted
|
N
|
65
|
58
|
44
|
21
|
12
| |
|
Mean (SD)
|
85.8 (17.4)
|
88.9 (21)
|
87 (19.1)
|
85 (23.9)
|
79.9 (17.8)
| |
|
Range
|
50–126
|
42–147
|
54–120
|
39–116
|
46–101
| |
|
Median (IQR)
|
88 (26)
|
89 (29)
|
88.5 (28)
|
89 (28)
|
84 (23)
| |
|
Estimated mean (95% CI)*
|
85.8 (81.5; 90.1)
|
87.7 (82.5; 92.8)
|
86.1 (80.6; 91.5)
|
83.8 (77; 90.7)
|
84.5 (77.4; 91.7)
|
p = 0.0007
|
|
GAP index#
|
N
|
65
| |
44
| |
11
| |
|
Stage 1 n (%)
|
35 (13.8)
| |
24 (54.5)
| |
7 (63.6)
| |
|
Stage 2 n (%)
|
30 (46.2)
| |
17 (38.6)
| |
4 (36.4)
| |
|
Stage 3 n (%)
|
0
| |
3 (6.8)
| |
0
| |
|
6MWD Meters (measured)#
|
N
|
18
| |
5
| |
1
| |
|
Mean (SD)
|
474. 9 (128.3)
| |
325,4 (225.5)
| |
NA
| |
|
Range
|
140–666
| |
50–595
| |
300
| |
|
Median (IQR)
|
461 (164)
| |
388 (430)
| |
NA
| |
|
6MWD %predicted#
|
N
|
17
| |
5
| |
1
| |
|
Mean (SD)
|
79 (141)
| |
55,6 (37.3)
| |
NA
| |
|
Range
|
48–101
| |
8–87
| |
57
| |
|
Median (IQR)
|
82.5 (19)
| |
74 (63)
| |
NA
| |
- Legend: Significant p-values are indicated in bold
- N refers to the number of participants who filled in the questionnaire or for whom the variable was applicable
- # Variables of which the evolution over time is not assessed
- *For the ‘BMI category’, only the main effect of time (p-value) is reported in this table
- We refer the readers to Additional file 1: table S4 for the pairwise comparisons between timepoints
- Abbreviations: BMI (body mass index, DLco (diffusing capacity for monoxide), FVC (forced vital capacity, GAP-index (gender-age-physiological-index), 6MWD (six-minute walk test)
