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Table 2 Clinical characteristics

From: Behavioural and psychological patterns of patients with idiopathic pulmonary fibrosis: a prospective study

 

Baseline (Visit 1)

Three months (Visit 3)

One year (Visit 4)

One year and a half (Visit 5)

Two years (Visit 6)

Main effect of time

Weight (Kg)

N

66

 

45

 

12

 

Mean (SD)

82.5 (16)

 

83 (13.1)

 

82.3 (10.6)

 

Range

46–129

 

54–112

 

71–100

 

Median (IQR)

83 (17.6)

 

83 (18)

 

79.5 (20)

 

Estimated mean (95% CI)*

82.5 (78.6; 86.4)

 

80.9 (77.2; 84.6)

 

78.6 (74.5; 81.7)

p = 0.0110

BMI (Kg/m2)

N

66

 

45

 

12

 

Mean (SD)

28.6 (4.4)

 

28.5 (4)

 

27.3 (3.3)

 

Range

19.8–40.4

 

21–37.8

 

20.8–32.4

 

Median (IQR)

28.1 (5.9)

 

27.6 (6.4)

 

27.1 (3.2)

 

Estimated mean (95% CI)*

28.6 (27.5; 29.6)

 

28.0 (27; 29)

 

27.1 (26; 28.3)

p = 0.0061

BMI category

N

66

 

45

 

12

 

Underweight n (%)

0

 

0

 

0

 

Normal n (%)

13 (9.7)

 

9 (20.0)

 

2 (16.7)

 

Overweight n (%)

27 (40.9)

 

19 (42.2)

 

8 (66.7)

 

Obese n (%)

26 (39.4)

 

17 (37.8)

 

2 (16.7)

 

Main effect of time*

 

p = 0.0992

Smoking status#

N

66

  

Never n (%)

14 (21.2)

  

Former n (%)

52 (78.8)

  

Oxygen use#

N

66

 

46

 

13

 

Yes n (%)

1 (1.5)

 

7 (15.2)

 

2 (15.4)

 

Continuous use

1 (100)

 

5 (83.3)

 

2 (100)

 

Exercise and sleep

0

 

1 (16.7)

 

0

 

Gastro oesophageal reflux#

N

66

  

Yes n (%)

9 (13.6)

  

DLco % predicted

N

65

56

44

21

11

 

Mean (SD)

56.9 (15.7)

57.8 (15)

55.1 (15.4)

54.2 (17.4)

58.5 (17.6)

 

Range

24–111

21–103

23–99

25–102

42–98

 

Median (IQR)

57 (18)

56.5 (13)

56 (17)

51 (19)

51 (22)

 

Estimated mean (95% CI)*

56.9 (53; 60.7)

56.1(52.3;59.8)

53.2 (49.1; 57.3)

50.9 (46.3; 55.5)

49 (44.4; 53.7)

p < 0.0001

FVC % predicted

N

65

58

44

21

12

 

Mean (SD)

85.8 (17.4)

88.9 (21)

87 (19.1)

85 (23.9)

79.9 (17.8)

 

Range

50–126

42–147

54–120

39–116

46–101

 

Median (IQR)

88 (26)

89 (29)

88.5 (28)

89 (28)

84 (23)

 

Estimated mean (95% CI)*

85.8 (81.5; 90.1)

87.7 (82.5; 92.8)

86.1 (80.6; 91.5)

83.8 (77; 90.7)

84.5 (77.4; 91.7)

p = 0.0007

GAP index#

N

65

 

44

 

11

 

Stage 1 n (%)

35 (13.8)

 

24 (54.5)

 

7 (63.6)

 

Stage 2 n (%)

30 (46.2)

 

17 (38.6)

 

4 (36.4)

 

Stage 3 n (%)

0

 

3 (6.8)

 

0

 

6MWD Meters (measured)#

N

18

 

5

 

1

 

Mean (SD)

474. 9 (128.3)

 

325,4 (225.5)

 

NA

 

Range

140–666

 

50–595

 

300

 

Median (IQR)

461 (164)

 

388 (430)

 

NA

 

6MWD %predicted#

N

17

 

5

 

1

 

Mean (SD)

79 (141)

 

55,6 (37.3)

 

NA

 

Range

48–101

 

8–87

 

57

 

Median (IQR)

82.5 (19)

 

74 (63)

 

NA

 
  1. Legend: Significant p-values are indicated in bold
  2. N refers to the number of participants who filled in the questionnaire or for whom the variable was applicable
  3. # Variables of which the evolution over time is not assessed
  4. *For the ‘BMI category’, only the main effect of time (p-value) is reported in this table
  5. We refer the readers to Additional file 1: table S4 for the pairwise comparisons between timepoints
  6. Abbreviations: BMI (body mass index, DLco (diffusing capacity for monoxide), FVC (forced vital capacity, GAP-index (gender-age-physiological-index), 6MWD (six-minute walk test)
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Respiratory Research

ISSN: 1465-993X

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