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Table 2 Clinical characteristics

From: Behavioural and psychological patterns of patients with idiopathic pulmonary fibrosis: a prospective study

  Baseline (Visit 1) Three months (Visit 3) One year (Visit 4) One year and a half (Visit 5) Two years (Visit 6) Main effect of time
Weight (Kg) N 66   45   12  
Mean (SD) 82.5 (16)   83 (13.1)   82.3 (10.6)  
Range 46–129   54–112   71–100  
Median (IQR) 83 (17.6)   83 (18)   79.5 (20)  
Estimated mean (95% CI)* 82.5 (78.6; 86.4)   80.9 (77.2; 84.6)   78.6 (74.5; 81.7) p = 0.0110
BMI (Kg/m2) N 66   45   12  
Mean (SD) 28.6 (4.4)   28.5 (4)   27.3 (3.3)  
Range 19.8–40.4   21–37.8   20.8–32.4  
Median (IQR) 28.1 (5.9)   27.6 (6.4)   27.1 (3.2)  
Estimated mean (95% CI)* 28.6 (27.5; 29.6)   28.0 (27; 29)   27.1 (26; 28.3) p = 0.0061
BMI category N 66   45   12  
Underweight n (%) 0   0   0  
Normal n (%) 13 (9.7)   9 (20.0)   2 (16.7)  
Overweight n (%) 27 (40.9)   19 (42.2)   8 (66.7)  
Obese n (%) 26 (39.4)   17 (37.8)   2 (16.7)  
Main effect of time*   p = 0.0992
Smoking status# N 66   
Never n (%) 14 (21.2)   
Former n (%) 52 (78.8)   
Oxygen use# N 66   46   13  
Yes n (%) 1 (1.5)   7 (15.2)   2 (15.4)  
Continuous use 1 (100)   5 (83.3)   2 (100)  
Exercise and sleep 0   1 (16.7)   0  
Gastro oesophageal reflux# N 66   
Yes n (%) 9 (13.6)   
DLco % predicted N 65 56 44 21 11  
Mean (SD) 56.9 (15.7) 57.8 (15) 55.1 (15.4) 54.2 (17.4) 58.5 (17.6)  
Range 24–111 21–103 23–99 25–102 42–98  
Median (IQR) 57 (18) 56.5 (13) 56 (17) 51 (19) 51 (22)  
Estimated mean (95% CI)* 56.9 (53; 60.7) 56.1(52.3;59.8) 53.2 (49.1; 57.3) 50.9 (46.3; 55.5) 49 (44.4; 53.7) p < 0.0001
FVC % predicted N 65 58 44 21 12  
Mean (SD) 85.8 (17.4) 88.9 (21) 87 (19.1) 85 (23.9) 79.9 (17.8)  
Range 50–126 42–147 54–120 39–116 46–101  
Median (IQR) 88 (26) 89 (29) 88.5 (28) 89 (28) 84 (23)  
Estimated mean (95% CI)* 85.8 (81.5; 90.1) 87.7 (82.5; 92.8) 86.1 (80.6; 91.5) 83.8 (77; 90.7) 84.5 (77.4; 91.7) p = 0.0007
GAP index# N 65   44   11  
Stage 1 n (%) 35 (13.8)   24 (54.5)   7 (63.6)  
Stage 2 n (%) 30 (46.2)   17 (38.6)   4 (36.4)  
Stage 3 n (%) 0   3 (6.8)   0  
6MWD Meters (measured)# N 18   5   1  
Mean (SD) 474. 9 (128.3)   325,4 (225.5)   NA  
Range 140–666   50–595   300  
Median (IQR) 461 (164)   388 (430)   NA  
6MWD %predicted# N 17   5   1  
Mean (SD) 79 (141)   55,6 (37.3)   NA  
Range 48–101   8–87   57  
Median (IQR) 82.5 (19)   74 (63)   NA  
  1. Legend: Significant p-values are indicated in bold
  2. N refers to the number of participants who filled in the questionnaire or for whom the variable was applicable
  3. # Variables of which the evolution over time is not assessed
  4. *For the ‘BMI category’, only the main effect of time (p-value) is reported in this table
  5. We refer the readers to Additional file 1: table S4 for the pairwise comparisons between timepoints
  6. Abbreviations: BMI (body mass index, DLco (diffusing capacity for monoxide), FVC (forced vital capacity, GAP-index (gender-age-physiological-index), 6MWD (six-minute walk test)