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Fig. 7 | Respiratory Research

Fig. 7

From: Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease

Fig. 7

The diagram of mechanism underlying HE4 regulation in COPD. Cigarette smoke promotes HE4 expression and secretion in bronchial epithelial cells partly through oxidative stress, and then mediated IL-6 production via the phosphorylation of NFκB-p65 to participate in airway inflammation. The elevated HE4 release from bronchial epithelial cells facilitates fibroblast to myofibroblast differentiation and fibroblastic proliferation to aggravate airway remodeling. HE4, human epididymis protein 4; ROS, reactive oxygen species; IL-6, interleukin-6; COPD, chronic obstructive pulmonary disease

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Respiratory Research

ISSN: 1465-993X

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