Fig. 6From: The role of retinoid-related orphan receptor-α in cigarette smoke-induced autophagic responseSchematic summary showing the proposed role of RORα on cigarette smoke-induced autophagy. The increase in RORα by smoking induces activity of the p53-DRAM axis through direct binding with p53 and then induces an increase in autophagy, leading to an increase in cell deathBack to article page