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Fig. 3 | Respiratory Research

Fig. 3

From: PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model

Fig. 3

PEDF could inhibit fibrosis induced by BLM. A Representative images of the H&E and Masson-stained cross-section of the lung from the experimental group (BLM 5 mg/kg or 2 mg/kg) and PEDF-AAV (denoted as PEDF) treatment group or PEDF-shRNA-AAV (denoted as shPEDF) treatment group. BLM (2 mg/kg or 5 mg/kg) represents lung tissue from rats 28 days after BLM instillation. Bar = 200 μm. B The Ashcroft score among multiple groups. C Quantification of hydroxyproline content in lung tissue of each group. Data are expressed as the mean ± SD, n = 6, *P < 0.05; **P < 0.01; ***P < 0.001

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