Fig. 1

Progression characteristics of BLM-induced IPF. A H&E and Masson-stained cross-section of the lung from normal and BLM-exposed rats (3 days, 7 days, 14 days, 21 days, 28 days, 42 days, 56 days). Bar = 200 μm. C The Ashcroft score among multiple groups. D Quantification of hydroxyproline content in lung tissue. E TGF-β1 mRNA and F VEGF mRNA expression was measured by real-time PCR. G TGF-β1 and H VEGF content of lung tissue from multiple groups. Data are expressed as the mean ± SD, n = 6, experimental group vs normal group, NS, no significant difference; *P < 0.05; **P < 0.01; ***P < 0.001