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Table 3 Associations between steroid administration and changes in quantitative chest CT parameters (%) in the entire cohort

From: Usage of compromised lung volume in monitoring steroid therapy on severe COVID-19

Outcome

Unadjusted

Adjusted

Changes in quantitative CT parameters (%)

Coefficient

95% CI

P value

Coefficient

95% CI

P value

Changes in CLa

 − 7.44

 − 10.01 to − 4.87

 < 0.01

 − 3.27

 − 5.86 to − 0.68

0.01

Changes in NNLb

 − 1.75

 − 3.01 to − 0.48

 < 0.01

 − 0.68

 − 1.61 to 0.24

0.15

Changes in PALc

 − 5.71

 − 7.66 to − 3.77

 < 0.01

 − 1.44

 − 3.46 to 0.57

0.16

Changes in NALd

7.46

4.03 to 10.88

 < 0.01

6.17

3.51 to 8.83

 < 0.01

Changes in HIe

0.06

 − 2.81 to 2.92

0.97

 − 1.86

 − 4.73 to 1.01

0.20

  1. Analyses using generalized estimating equations to implement linear regression models. Coefficients represent differences in changes in quantitative chest CT parameters associated with steroid administration. All analyses were adjusted for duration and baseline quantitative chest CT parameters. a Model adjusted for duration and baseline %CL; b Model adjusted for duration and baseline %NNL; c Model adjusted for duration and baseline %PAL; d Model adjusted for duration and baseline %NAL; e Model adjusted for duration and baseline %HI. %CL, percentage of compromised lung volume, calculated as the sum of %PAL and %NNL; %NNL, percentage of nonaerated lung volume; %PAL, percentage of poorly aerated lung volume; %NAL, percentage of normally aerated lung volume; %HI, percentage of hyperinflated lung volume