|
24 CTEPH patients
|
p
|
---|
Before BPA
|
After BPA
|
---|
Patient characteristics
|
Age (years)
|
59 ± 10
|
–
|
Female (%)
|
18 (75%)
|
–
|
Number of BPA sessions/patient
|
3 (2,4)
|
–
|
Duration to follow-up (days)
|
115 (81, 177)
|
–
|
PAH targeted therapy (%)
|
11 (45.8%)
| |
Hemodynamics
|
Heart rate
|
79.8 ± 15.3
|
69.5 ± 10.1
|
0.009
|
Mean RAP (mmHg)
|
7.9 ± 4.0
|
5.5 ± 3.4
|
0.062
|
Systolic PAP (mmHg)
|
70.8 ± 25.0
|
50.3 ± 14.2
|
0.001
|
Diastolic PAP (mmHg)
|
23.5 ± 9.1
|
15.8 ± 6.0
|
0.001
|
Mean PAP (mmHg)
|
40.6 ± 13.8
|
28.5 ± 8.0
|
0.001
|
PVR (Wood unit)
|
8.0 (3.7,17.0)
|
4.0 (2.9, 5.4)
|
0.007
|
Cardiac output (L/min)
|
3.5 (2.6, 5.4)
|
4.7 (3.7, 5.8)
|
0.017
|
Cardiac index (L/min/m2)
|
2.2 (1.8, 3.4)
|
2.9 (2.5, 3.5)
|
0.044
|
PASO2 (%)
|
64.1 ± 9.5
|
68.7 ± 7.2
|
0.068
|
MVSO2 (%)
|
93.7 ± 3.4
|
95.2 ± 3.0
|
0.116
|
NT-proBNP (pg/ml)
|
171.0 (71.5, 1569.0)
|
50.6 (26.5, 113.4)
|
0.002
|
Exercise capacity
|
WHO functional class (I–II/III–IV, %)
|
50.0%/50.0%
|
95.8%/4.2%
|
< 0.001
|
Absolute change of 6MWD (meters)
|
88.0 ± 55.5
|
< 0.001
|
- Continuous variables are expressed as mean ± standard deviation or median and interquartile range according to variable distribution
- CTEPH chronic thromboembolic pulmonary hypertension, BPA balloon pulmonary angioplasty, RAP right atrium pressure, PAP pulmonary artery pressure, PVR pulmonary vascular resistance, PASO2 pulmonary arterial oxygen saturation, MVSO2 mixed venous oxygen saturation, NT-proBNP N-terminal pro-B-type natriuretic peptide, WHO World Health Organization, 6MWD 6-min walk distance