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Table 4 Statistical Analysis of Variables Correlated with the Occurrence of complications

From: Bilateral versus unilateral balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension

  Univariate analysis Multivariate analysis
Odds Ratio 95% CI p value Odds Ratio 95% CI p value
Age (years) 0.998 0.958–1.040 0.928
Sex (female) 0.943 0.359–2.481 0.906
Bilateral 1.201 0.475–3.035 0.699
First session 1.160 0.523–2.572 0.715
WHO functional class (III-IV versus I-II) 3.981 1.540–10.290 0.004 3.268 1.216–8.781 0.019
Period of BPA procedure (recent versus initial period#) 0.613 0.240–1.567 0.307
Mean PAP (mmHg) 1.046 1.004–1.090 0.030
PVR (Wood Unit) 1.109 1.029–1.195 0.007 1.085 1.004–1.172 0.040
Cardiac index (L/min/m2) 0.543 0.291–1.014 0.055
Vessels treated/session 1.126 0.977–1.297 0.102
Lobes treated/session 1.573 1.019–2.427 0.041
Lesions treated/session 1.026 0.910–1.155 0.677
Complex lesions treated/session 0.732 0.469–1.141 0.168
Largest balloon size used/session (mm) 0.654 0.428–1.001 0.050
NT-proBNP (pg/ml) 1.000246 1.000052–1.000440 0.013
The amount of contrast media given (ml) 1.000 0.993–1.007 0.949
Dose area product (μGy m2) 0.999919 0.999736–1.000102 0.385
Operation duration 1.005 0.998–1.013 0.144
  1. Multivariate analysis was made using variables with significant correlation of p < 0.01 in univariate analysis
  2. CI confidence intervals, PAP pulmonary artery pressure, PVR pulmonary vascular resistance, NT-proBNP N-terminal pro-B-type natriuretic peptide, WHO World Health Organization
  3. *Complex lesions were defined as subtotal occlusions and total occlusions. #Initial period was defined by the initial 105 BPA sessions (50%) performed between January 2019 and June 2020. The recent period was defined by the recent 105 BPA sessions (50%) performed between July 2020 and November 2021