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Table 2 Lung mechanics of patients in each study group

From: Rapidly improving acute respiratory distress syndrome in COVID-19: a multi-centre observational study

 

All

(n = 280)

Rapidly improving ARDS group (n = 11)

Intermediate group (n = 235)

Persistent severe ARDS

group (n = 34)

p value

Lung mechanics on the day of intubation

Ventilation mode

    

0.955

 Volume control

238 (85.0)

9 (81.8)

200 (85.1)

29 (85.3)

 

 Pressure control

42 (15.0)

2 (18.2)

35 (14.9)

5 (14.7)

 

Respiratory rate, bpm

25.0 (22.0–27.0)

22.0 (18.0–26.0)

25.0 (22.0–27.0)

25.0 (22.0–28.0)

0.136

Tidal volume, mL

450.0 (390.0–480.0)

430.0 (380.0–480.0)

450.0 (400.0–480.0)

425.0 (380.0–450.0)

0.067

Tidal volume/predicted body weight, mL/kg

6.4 (5.9–7.2)

7.2 (5.8–7.9)

6.5 (5.9–7.2)

6.0 (5.3–6.4)

0.021c

PEEPext, cmH2O

12.0 (10.0–14.0)

12.0 (10.0–14.0)

12.0 (10.0–14.0)

10.0 (10.0–13.0)

0.704

PEEPtotal, cmH2O

12.0 (10.0–14.0)

12.0 (10.5–14.0)

12.0 (10.0–14.0)

11.0 (10.0–13.0)

0.343

Pplateau, cmH2O

26.0 (22.0–28.0)

23.5 (20.0–26.3)

25.0 (22.0–28.0)

28.0 (25.0–30.0)

0.005b,c

Pdriving, cmH2O

13.0 (11.0–15.0)

12.0 (8.8–13.0)

12.0 (11.0–15.0)

15.0 (12.8–17.3)

0.001b,c

Compliance of respiratory system, mL/cmH2O

33.6 (28.9–40.9)

36.2 (30.5–49.0)

34.3 (29.2–41.7)

29.4 (22.3–33.6)

0.001b,c

FiO2

0.8 (0.6–1.0)

0.6 (0.5–1.0)

0.8 (0.6–1.0)

1.0 (0.7–1.0)

0.003b,c

PaO2, mmHg

88.0 (73.0–111.0)

101.0 (90.0–162.0)

88.0 (73.0–110.0)

84.0 (65.0–113.5)

0.164

PaO2:FiO2

125.0 (93.0–161.0)

202.0 (162.0–227.0)

125.0 (96.0–160.0)

99.0 (73.0–150.0)

 < 0.001a,b

PaCO2, mmHg

46.0 (39.0–56.0)

45.0 (39.5–52.7)

46.0 (39.0–56.0)

50.0 (41.0–60.5)

0.421

Lung mechanics on the first day following intubation

Ventilation mode

    

1.0

 Volume control

274 (98.2)

11 (100.0)

229 (97.9)

34 (100.0)

 

 Pressure support

5 (1.8)

0 (0.0)

5 (2.1)

0 (0.0)

 

FiO2

0.6 (0.5–0.7)

0.4 (0.4–0.5)

0.6 (0.5–0.7)

0.8 (0.7–0.9)

 < 0.001a−c

PaO2, mmHg

90.0 (79.0–109.0)

141.0 (110.0–180.0)

90.0 (80.0–109.0)

85.0 (75.3–98.0)

 < 0.001a,b

PaO2:FiO2

157.0 (127.0–201.8)

353.0 (314.0–368.0)

162.0 (134.0–200.0)

111.5 (91.5–135.8)

 < 0.001a−c

Lung mechanics on the second day following intubation

Positive fluid balance

231 (84.0)

9 (81.8)

194 (82.9)

28 (93.3)

0.304

Fluid balance, mL

1333.0 (420.0–2535.0)

1020.0 (737.0–1845.0)

1268.5 (350.0–2475.0)

2188.0 (1146.5–4067.3)

0.013c

Still intubated

271 (98.5)

10 (90.9)

231 (98.7)

30 (100.0)

0.206

Ventilation mode

    

0.210

 Volume control

250 (94.0)

7 (87.5)

213 (93.4)

30 (100.0)

 

 Pressure support

16 (6.0)

1 (12.5)

15 (6.6)

0 (0.0)

 

Respiratory rate, bpm

26.0 (23.0–28.0)

25.0 (21.5–28.0)

25.0 (22.0–28.0)

28.0 (25.0–31.3)

0.026c

Tidal volume, mL

450.0 (400.0–480.0)

480.0 (385.0–495.0)

450.0 (400.0–480.0)

420.0 (375.0–452.5)

0.175

Tidal volume/predicted body weight, mL/kg

6.5 (6.0–7.2)

7.4 (6.0–8.1)

6.5 (6.0–7.3)

6.3 (5.8–6.7)

0.192

PEEPext, cmH2O

11.0 (9.0–12.0)

11.0 (8.3–13.0)

11.0 (9.0–12.0)

11.0 (8.8–14.3)

0.658

PEEPtotal, cmH2O

11.0 (9.0–13.0)

11.0 (9.0–13.0)

11.0 (9.0–13.0)

11.0 (9.0–14.0)

0.889

Pplateau, cmH2O

24.0 (22.0–27.0)

22.5 (19.5–24.5)

24.0 (22.0–27.0)

28.0 (24.0–31.0)

 < 0.001b,c

Pdriving, cmH2O

13.0 (11.0–15.0)

11.0 (9.0–13.0)

12.0 (10.0–14.0)

15.0 (14.0–19.0)

 < 0.001b,c

Compliance of respiratory system, mL/cmH2O

33.3 (28.0–40.9)

37.4 (30.2–40.2)

34.1 (28.6–43.2)

26.4 (22.1–31.4)

 < 0.001c

FiO2

0.6 (0.5–0.7)

0.4 (0.4–0.5)

0.5 (0.5–0.6)

0.9 (0.8–1.0)

 < 0.001a−c

PaO2, mmHg

89.0 (77.0–102.3)

97.0 (85.9–154.0)

91.0 (79.5–104.5)

67.5 (61.5–84.0)

 < 0.001b,c

PaO2:FiO2

167.0 (137.0–211.5)

243.0 (218.0–350.0)

169.5 (144.0–211.8)

82.0 (68.8–95.3)

 < 0.001a−c

PaCO2, mmHg

45.0 (41.0–52.0)

40.0 (38.3–45.0)

45.5 (41.3–52.0)

47.5 (43.5–62.3)

0.008b

  1. Data are presented as median (interquartile range) or number of patients (%)
  2. n number, ARDS acute respiratory distress syndrome, bpm breaths per minute, PEEP positive end expiratory pressure, Pplateau plateau pressure, Pdriving driving pressure, PaO2 partial pressure of arterial oxygen, FiO2 fraction of inspired oxygen, PaCO2 partial pressure of arterial carbon dioxide
  3. aDenotes statistical significance for the comparison between “rapidly improving ARDS” and “intermediate” groups
  4. bDenotes statistical significance for the comparison between “rapidly improving ARDS” and “persistent severe ARDS” groups
  5. cDenotes statistical significance for the comparison between “intermediate” and “persistent severe ARDS” groups
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Respiratory Research

ISSN: 1465-993X

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