|
Gene
|
COPD vs. control log2FC
|
Unadjusted p value
|
Adjusted p value
|
Overlap group
|
|---|
|
TGFB2
|
− 0.32
|
1.72E−15
|
3.51E−13
|
4
|
|
ZKSCAN1
|
− 0.14
|
8.44E−12
|
4.59E−10
|
2
|
|
PABPC4
|
0.14
|
1.99E−10
|
6.96E−09
|
1
|
|
MFAP2
|
0.27
|
1.87E−07
|
2.44E−06
|
1
|
|
ADAMTSL3*
|
− 0.18
|
4.48E−07
|
5.21E−06
|
4
|
|
AGER
|
− 0.23
|
5.32E−07
|
6.03E−06
|
4
|
|
PID1
|
0.16
|
5.00E−07
|
5.72–06
|
3
|
|
RPL23
|
0.11
|
9.15E−07
|
9.56–06
|
1
|
|
MFHAS1
|
0.11
|
1.22E−06
|
1.22E−05
|
3
|
|
BTC
|
− 0.17
|
2.27E−05
|
1.47E−04
|
2
|
|
CHRM3
|
− 0.28
|
4.39E−05
|
2.60E−04
|
4
|
|
SFTPD
|
0.17
|
1.10E−04
|
5.80E−04
|
3
|
|
MED13L
|
− 0.06
|
1.04E−04
|
5.47E−04
|
4
|
|
NR4A2
|
0.45
|
3.20E−04
|
1.42E−03
|
3
|
|
ZBTB38
|
− 0.06
|
3.40E−04
|
1.48E−03
|
4
|
|
HHIP
|
0.19
|
1.73E−03
|
5.92E−03
|
3
|
|
RIN3*
|
0.07
|
2.09E−03
|
6.93E−03
|
3
|
|
CITED2
|
0.16
|
2.21E−03
|
7.28E−03
|
3
|
- The gene nearest to each lead GWAS single nucleotide polymorphism is included
- COPD vs. control log2FC, unadjusted p values, and Benjamini–Hochberg adjusted p value shown. Genes identified as eQTLs denoted with *. Group 1: genes with increased expression in IPF and COPD; Group 2: genes with increased expression in IPF but decreased expression in COPD; Group 3: genes with decreased expression in IPF but increased expression in COPD; Group 4: genes with decreased expression in IPF and COPD
- COPD chronic obstructive pulmonary disease, GWAS genome-wide association study, log2FC log2 fold change, eQTL expression quantitative trait locus
