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Table 2 COPD GWAS [1] genes in the overlapping differentially expressed gene groups

From: Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

Gene

COPD vs. control log2FC

Unadjusted p value

Adjusted p value

Overlap group

TGFB2

− 0.32

1.72E−15

3.51E−13

4

ZKSCAN1

− 0.14

8.44E−12

4.59E−10

2

PABPC4

0.14

1.99E−10

6.96E−09

1

MFAP2

0.27

1.87E−07

2.44E−06

1

ADAMTSL3*

− 0.18

4.48E−07

5.21E−06

4

AGER

− 0.23

5.32E−07

6.03E−06

4

PID1

0.16

5.00E−07

5.72–06

3

RPL23

0.11

9.15E−07

9.56–06

1

MFHAS1

0.11

1.22E−06

1.22E−05

3

BTC

− 0.17

2.27E−05

1.47E−04

2

CHRM3

− 0.28

4.39E−05

2.60E−04

4

SFTPD

0.17

1.10E−04

5.80E−04

3

MED13L

− 0.06

1.04E−04

5.47E−04

4

NR4A2

0.45

3.20E−04

1.42E−03

3

ZBTB38

− 0.06

3.40E−04

1.48E−03

4

HHIP

0.19

1.73E−03

5.92E−03

3

RIN3*

0.07

2.09E−03

6.93E−03

3

CITED2

0.16

2.21E−03

7.28E−03

3

  1. The gene nearest to each lead GWAS single nucleotide polymorphism is included
  2. COPD vs. control log2FC, unadjusted p values, and Benjamini–Hochberg adjusted p value shown. Genes identified as eQTLs denoted with *. Group 1: genes with increased expression in IPF and COPD; Group 2: genes with increased expression in IPF but decreased expression in COPD; Group 3: genes with decreased expression in IPF but increased expression in COPD; Group 4: genes with decreased expression in IPF and COPD
  3. COPD chronic obstructive pulmonary disease, GWAS genome-wide association study, log2FC log2 fold change, eQTL expression quantitative trait locus