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Table 2 COPD GWAS [1] genes in the overlapping differentially expressed gene groups

From: Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

Gene COPD vs. control log2FC Unadjusted p value Adjusted p value Overlap group
TGFB2 − 0.32 1.72E−15 3.51E−13 4
ZKSCAN1 − 0.14 8.44E−12 4.59E−10 2
PABPC4 0.14 1.99E−10 6.96E−09 1
MFAP2 0.27 1.87E−07 2.44E−06 1
ADAMTSL3* − 0.18 4.48E−07 5.21E−06 4
AGER − 0.23 5.32E−07 6.03E−06 4
PID1 0.16 5.00E−07 5.72–06 3
RPL23 0.11 9.15E−07 9.56–06 1
MFHAS1 0.11 1.22E−06 1.22E−05 3
BTC − 0.17 2.27E−05 1.47E−04 2
CHRM3 − 0.28 4.39E−05 2.60E−04 4
SFTPD 0.17 1.10E−04 5.80E−04 3
MED13L − 0.06 1.04E−04 5.47E−04 4
NR4A2 0.45 3.20E−04 1.42E−03 3
ZBTB38 − 0.06 3.40E−04 1.48E−03 4
HHIP 0.19 1.73E−03 5.92E−03 3
RIN3* 0.07 2.09E−03 6.93E−03 3
CITED2 0.16 2.21E−03 7.28E−03 3
  1. The gene nearest to each lead GWAS single nucleotide polymorphism is included
  2. COPD vs. control log2FC, unadjusted p values, and Benjamini–Hochberg adjusted p value shown. Genes identified as eQTLs denoted with *. Group 1: genes with increased expression in IPF and COPD; Group 2: genes with increased expression in IPF but decreased expression in COPD; Group 3: genes with decreased expression in IPF but increased expression in COPD; Group 4: genes with decreased expression in IPF and COPD
  3. COPD chronic obstructive pulmonary disease, GWAS genome-wide association study, log2FC log2 fold change, eQTL expression quantitative trait locus