Fig. 5

Association of GSVA scores from overlap groups with FEV₁% predicted in LTRC. Scatterplots with trend lines of association of GSVA scores from overlap groups with FEV₁% predicted in LTRC subjects. Turquoise represents COPD cases, purple represents IPF cases, and gray represents all other diagnoses. Trend lines are colored to represent overlap group. Spearman correlation coefficient and p value are shown for each association. Group 1: genes with increased expression in IPF and COPD; Group 2: genes with increased expression in IPF but decreased expression in COPD; Group 3: genes with decreased expression in IPF but increased expression in COPD; Group 4: genes with decreased expression in IPF and COPD. A Association of GSVA score from Group 1 genes with FEV₁% predicted. B Association of GSVA score from Group 2 genes with FEV₁% predicted. C Association of GSVA score from Group 3 with FEV₁% predicted. D Association of GSVA score from Group 4 with FEV₁% predicted. GSVA gene set variation analysis, LTRC Lung Tissue Research Consortium, COPD chronic obstructive pulmonary disease, IPF idiopathic pulmonary fibrosis, FEV₁ forced expiratory volume over 1 s