Fig. 4

Cell category composition of differentially expressed genes and cell deconvolution in IPF and COPD. A Histogram of differentially expressed genes in LTRC in each overlap group by single cell RNA sequencing (scRNASeq) defined cell category [26]. Cell category genes were defined by top 5 scRNASeq genes differentially expressed by each cell type within each category. Group 1: genes with increased expression in IPF and COPD; Group 2: genes with increased expression in IPF but decreased expression in COPD; Group 3: genes with decreased expression in IPF but increased expression in COPD; Group 4: genes with decreased expression in IPF and COPD. B Selected COPD-associated deconvoluted cell type proportion distributions across COPD, IPF, and control samples. C Selected IPF-associated deconvoluted cell type proportion distributions across COPD, IPF, and control samples