Fig. 3

Hallmark pathway enrichment. A Heatmap of enrichment scores for differentially expressed genes in IPF and COPD vs. control with hierarchical clustering. Cells in red denote positive enrichment score whereas cells in blue denote negative enrichment score. B Density plot of genes ranks in IPF on x axis and gene ranks in COPD on y axis in TNF-alpha signaling via NFKB pathway. Color gradient represents the number of genes at the given rank coordinates, where darker shades of red denote the location with the highest number of genes and lighter shades of yellow denote the location with the lowest number genes. C Density plot of genes ranks in IPF on x axis and gene ranks in COPD on y axis in epithelial mesenchymal transition pathway. D Density plot of gene ranks in IPF on x axis and gene ranks in COPD on y axis in inflammatory response pathway. E Density plot of gene ranks in IPF on x axis and gene ranks in COPD on y axis in TGF Beta signaling pathway