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Fig. 6 | Respiratory Research

Fig. 6

From: C/EBP homologous protein promotes Sonic Hedgehog secretion from type II alveolar epithelial cells and activates Hedgehog signaling pathway of fibroblast in pulmonary fibrosis

Fig. 6

LV-Chop-shRNA promotes survival of tunicamycin aggravated pulmonary fibrosis by bleomycin. A Schematic of the experimental study in C57BL/6 mice. shChop, LV-Chop-shRNA; TM, tunicamycin; bleo, bleomycin. B Kaplan–Meier analysis for TM/bleo mice treated with or without shCHOP. n = 10 biological independent animals per group. C Gating strategy for flowcytometric sorting of EpCAM positive epithelial cells of mouse lung. D mRNA level of CHOP and Shh of sorted epithelial cells relative to control. Each dot represents cells from an independent mouse. n = 10 per group. E Representative immunofluorescence images on mouse lung. AECII was labeled with pro-SPC (green) and Shh (red). Bar = 50 μm. F Quantification of the percentage of Shh positive AECII in mouse lung. Each dot represents cell numbers in one field. n = 10 per group

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Respiratory Research

ISSN: 1465-993X

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