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Fig. 5 | Respiratory Research

Fig. 5

From: Efficacy, dose–response, and aerosol delivery of dry powder synthetic lung surfactant treatment in surfactant-deficient rabbits and premature lambs

Fig. 5

Arterial pH, partial arterial oxygen pressure (PaO2), and partial arterial carbon dioxide pressure (PaCO2), and lung volume (mean ± SEM) in the three groups of premature lambs supported with nCPAP and 100% oxygen and treated with 1 or 2 doses of aerosolized B-YL:Trehalose surfactant or the positive control Curosurf. Data reflect the period from birth until 180 min post-surfactant treatment for PaO2 (A), PaCO2 (B), and pH (C), whereas lung volumes were derived from postmortem pressure–volume curves (D). MV: mechanical ventilation. *p < 0.02 for 2-dose B-YL:Trehalose and Curosurf groups vs the 1-dose B-YL:Trehalose group; #p = 0.045 for the Curosurf vs the 1- and 2-dose B-YL:Trehalose groups; p = 0.012 for Curosurf vs the 1-dose BYL:Trehalose group

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