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Table 3 Pulmonary functional tests

From: Combined obstructive airflow limitation associated with interstitial lung diseases (O-ILD): the bad phenotype ?

 

Non O-ILD

(n = 475)

O-ILD

(n = 82)

p-value

Pulmonary functional test

   

 FEV1 (L)

2.31 (1.76–2.88)

1.75 (1.38–2.41)

 < 0.0001

 FEV1 (%pred.)

83 (71–96)

65 (53–77)

 < 0.0001

 FVC (L)

2.81 (2.16–3.64)

2.99 (2.32–3.89)

n.s

 FVC (%pred.)

83 (69–96)

84 (72–98)

n.s

 FEV1/FVCpost-BD

81 (77–86)

62 (58–67)

 < 0.0001

 MEF25/75 (L)

2.49 (1.87–3.17)

1.02 (0.60–1.36)

 < 0.0001

 MEF25/75 (%)

81 (64–108)

29 (20–41)

 < 0.0001

 RV (L)

1.76 (1.35–2.21)

2.43 (1.81–3.26)

 < 0.0001

 RV (%pred.)

83 (63–104)

116 (84–152)

 < 0.0001

 TLC (L)

4.73 (3.82–5.54)

5.78 (4.77–6.56)

 < 0.0001

 TLC (%pred.)

79 (69–91)

93 (82–107)

 < 0.0001

 DLco (mmol/kPa min)

4.67 (3.3–6.43)

4.94 (3.27–6.30)

n.s

 DLco (%pred.)

56 (41–67)

58 (41–67)

n.s

 KCO (mmol/kPa min/L)

1.18 (0.95–1.43)

1.09 (0.92–1.38)

n.s

 KCO (%pred.)

82 (68–97)

77 (65–92)

n.s

 FRC (L)

2.76 (2.33–3.56)

3.46 (2.94–4.64)

 < 0.0001

 FRC (%pred.)

92 (75–109)

113 (93–134)

 < 0.0001

 sGaw (L)a

1.15 (0.80–1.54)

0.69 (0.51–0.98)

 < 0.0001

 sGaw (%)b

87 (59–119)

60 (42–75)

 < 0.01

  1. Bold to indicate statistically significant p values
  2. Data are expressed as median (IQR). Values not available
  3. DLCO diffusing lung capacity of CO, FEV1 forced expired volume in 1s, FRC functional residual capacity, FVC forced vital capacity, ILD interstitial lung disease, KCO DLCO/Alveola ventilation, MEF maximum expiratory flow, NS/FS/CS non smokers/former smokers/current smokers, O- obstructive-, RV residual volume, TLC total lung capacity, sGaw specific conductances
  4. an = 396 ILD et 67 O-ILD
  5. bn = 208 ILD et 17 O-ILD