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Fig. 3 | Respiratory Research

Fig. 3

From: Progressive pulmonary fibrosis in a murine model of Hermansky-Pudlak syndrome

Fig. 3

Hps1ep/ep mice treated with 60 U/Kg bleomycin via subcutaneous minipump administration and euthanized 0, 2, 3, 4, and 6 weeks post pump implantation exhibited time-dependent fibrosis. A Masson’s trichrome stained lung slides (20×) of Hps1ep/ep mice at different time points show more severe fibrosis over time. The fibrosis is shown more in the subpleural and the peribrochovascular areas of the lungs. B Magnified images in selected fibrotic areas that are shown in A. C Hydroxyproline (HYP) content of the left lung of Hps1ep/ep mice as a fibrotic marker increases with time. One Way ANOVA test was done to calculate statistical significance

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