Fig. 2
From: Progressive pulmonary fibrosis in a murine model of Hermansky-Pudlak syndrome
Effect of subcutaneous minipump administration of bleomycin in Hps1ep/ep and C57BL/6 J wild type mice. A Percentage of body weight loss of Hps1ep/ep mice after treatment with 0 to 60 U/Kg bleomycin compared to Day 0. Body weight loss appears to be dose-dependent. B Masson’s Trichrome stained lung slides (20×) of Hps1ep/ep mice treated with 0, 15, 30, 45 and 60 U/Kg bleomycin. Fibrosis appeared dose-dependent. C Hydroxyproline (HYP) content of the left lung of both Hps1ep/ep and C57BL/6J mice. Hps1ep/ep mice exhibit higher susceptibility to develop bleomycin-induced PF. Statistical significance to determine P values as shown were ascertained through one-way ANOVA with multiple comparisons