Fig. 1

Variable severity of pulmonary fibrosis induced by oropharyngeal administration of bleomycin in Hps1^ep/ep mice or C57BL/6 J wild type mice. A Survival rates of Hps1^ep/ep mice with pulmonary fibrosis induced by oropharyngeal bleomycin (0.1–1 U/Kg) are variable and not dependent on bleomycin dose. B Percentage of body weight loss of Hps1^ep/ep mice on days 0 to 14 compared to baseline weight on day 0 (before bleomycin administration) is also variable. C Masson’s trichrome stained lung slides (20×) of Hps1^ep/ep mice treated with 0, 0.3 and 0.5 U/Kg compared to wild type C57BL/6J treated with 1 U/Kg bleomycin. An example of the variability in response to bleomycin administration which was not dose dependent: a dose of 0.3 U/Kg bleomycin caused some areas of fibrosis in addition to inflammation compared to higher doses of 0.5 U/Kg and 1 U/Kg that showed only major inflammation 14 days post the administration