|  | Rate per 100 (95% CI) |  |  |  | |
---|---|---|---|---|---|---|
 | Before propensity score matching | After propensity score matching | Hazard ratio (95% CI) | p value | ||
 | No metformin (n = 2222) | Metformin (n = 1100) | No metformin (n = 2222) | Metformin (n = 1100) | ||
Fracture | 4.57 (3.81, 5.48) | 2.54 (1.75, 3.68) | 4.00 (3.05, 5.25) | 3.01 (2.05, 4.4) | 0.75 (0.45, 1.21) | 0.23 |