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Table 2 Differences in clinical characteristics across phenotypes

From: Clinical phenotyping in sarcoidosis using cluster analysis

Characteristic1,2 1, N = 103 2, N = 45 3, N = 111 4, N = 114 5, N = 88 6, N = 93 q-value3
FEV1pp 104.4 (6.5) E 105.7 (11.5) E 91.8 (4.8) D 80.3 (6.1) C 71.2 (5.8) B 53.2 (12.4) A < 0.001
FVCpp 104.3 (6.6) E 107.9 (12.2) E 87.5 (5.3) C 89.5 (8.7) D 72.2 (5.3) B 66.3 (15.2) A < 0.001
FEV1/FVC 79.1 (4.8) D 76.4 (5.5) C 82.5 (4.0) E 70.3 (5.4) B 77.5 (6.2) C,D 63.5 (13.6) A < 0.001
Duration of disease (years) 2.0 (1.7) A 16.5 (9.9) E 4.2 (3.8) B 6.3 (4.8) C 2.0 (1.8) A 11.1 (9.5) D < 0.001
Ever treatment 39 (54.2%) A 16 (42.1%) A 52 (57.8%) A 74 (75.5%) B 54 (78.3%) B,C 75 (90.4%) C < 0.001
Scadding stage
 0 19 (20.2%) B,C 22 (48.9%) D 32 (31.7%) C,D 18 (16.4%) B 7 (9.0%) A,B 4 (4.9%) A < 0.001
 1 19 (20.2%) A 5 (11.1%) A 18 (17.8%) A 11 (10.0%) A 10 (12.8%) A 4 (4.9%) A
 2 39 (41.5%) B 8 (17.8%) A 33 (32.7%) A,B 35 (31.8%) A,B 47 (60.3%) C 21 (25.6%) A,B
 3 17 (18.1%) A 8 (17.8%) A 13 (12.9%) A 26 (23.6%) A 11 (14.1%) A 11 (13.4%) A
 4 0 (0.0%) A 2 (4.4%) A 5 (5.0%) A 20 (18.2%) B 3 (3.8%) A 42 (51.2%) C
BMI 28.8 (5.2) A 28.8 (6.0) A 31.8 (7.4) B 29.7 (6.1) A 32.9 (7.4) B 30.7 (7.3) A,B < 0.001
Age at diagnosis 47.4 (11.0) B 41.0 (11.6) A 47.8 (10.5) B 47.2 (11.2) B 49.6 (9.7) B 43.7 (10.7) A < 0.001
Female 56 (54.4%) A,B 30 (66.7%) B 70 (63.1%) B 47 (41.2%) A 47 (53.4%) A,B 39 (41.9%) A 0.004
Lofgren’s 6 (5.8%) A 3 (6.7%) A 6 (5.4%) A 0 (0.0%) A 1 (1.1%) A 1 (1.1%) A 0.016
Ever smoker 31 (30.4%) A,B 19 (42.2%) A,B 30 (27.0%) A 31 (27.4%) A 30 (34.1%) A,B 44 (47.3%) B 0.024
Race
 White 90 (90.0%) A 33 (75.0%) A 95 (86.4%) A 91 (79.8%) A 61 (72.6%) A 73 (81.1%) A 0.025
 Black 7 (7.0%) A 11 (25.0%) B 13 (11.8%) A,B 23 (20.2%) B 19 (22.6%) B 17 (18.9%) A,B
 Asian 1 (1.0%) 0 (0.0%) 1 (0.9%) 0 (0.0%) 2 (2.4%) 0 (0.0%)
 American Indian 1 (1.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (1.2%) 0 (0.0%)
 Other 1 (1.0%) 0 (0.0%) 1 (0.9%) 0 (0.0%) 1 (1.2%) 0 (0.0%)
Extrapulmonary Involvement 43 (41.7%) 21 (46.7%) 53 (47.7%) 62 (54.4%) 42 (47.7%) 38 (40.9%) 0.461
Cardiac 5 (4.9%) 6 (13.3%) 14 (12.6%) 23 (20.2%) 11 (12.5%) 12 (12.9%) 0.077
No. of organs 1.6 (1.0) 1.6 (1.1) 1.7 (1.1) 1.8 (1.0) 1.7 (1.0) 1.6 (1.0) 0.646
  1. 1Data presented: n (%); mean (SD)
  2. 2Statistical tests performed: Fisher’s exact test; Welch’s one-way ANOVA. For pairwise comparisons, 2-sample t-tests and logistic regression were performed; groups sharing the same letter (A, B, C, D, E) do not have significantly different means or proportions (q > 0.05)
  3. 3False discovery rate correction for multiple testing