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Fig. 4 | Respiratory Research

Fig. 4

From: miR-489-3p promotes malignant progression of non-small cell lung cancer through the inactivation of Wnt/β-catenin signaling pathway via regulating USP48

Fig. 4

MiR-489-3p mediates USP48 to inhibit the ubiquitination of β-catenin. A–B The starBase and qPCR screened out USP48 as the potential downstream target of miR-489-3p. C Co-IP assays proved the interaction between β-catenin and USP48. D–E RNA pulldown and luciferase reporter assays were performed for the detection of the interaction between USP48 and miR-489-3p. F Western blot detected the protein levels of β-catenin after CHX treatment and USP48 inhibition. G IP-western blot detected the ubiquitination of β-catenin after USP48 inhibition. **P < 0.01

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Respiratory Research

ISSN: 1465-993X

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