Roles of sirtuin family members in chronic obstructive pulmonary disease

Respiratory Research

Table 1 Molecular targets and functions of SIRT1 agonists

Species	Agonists	Molecular targets	Outcomes
Rat	Melatonin	NLRP3, IL-1β	Attenuate airway inflammation
Rat	Melatonin	CHOP and caspase-12	Attenuate apoptosis and endoplasmic reticulum stress
HBE cells	Melatonin	ORP150	Regulate endoplasmic reticulum stress reaction and autophagy
Rat	Resveratrol	PGC-1α	Antioxidant stress
Mice and HBE cells	Hydrogen sulfide	TGF-β1, Smad3	Reduce oxidative stress, modulate EMT and reduced airway remodeling
Mice and RAW264.7	Nucleosides	NF-κB/p65	Anti-inflammatory
Rat	Curcumin	LC3-I, LC3-II, Beclin 1, CHOP, and GRP78	Modulate autophagy and endoplasmic reticulum stress
RAW264.7	Andrographolide	ERK	Inhibit mitochondrial dysfunction, inflammation, and oxidative stress
HBE cells	Sodium hydrosulfide	ORP150	Regulate endoplasmic reticulum stress reaction and autophagy

NLRP3, NLR-family pyrin domain-containing protein 3; IL-1β, interleukin-1β; CHOP, C/EBP homologous protein; ORP150, oxygen-regulated protein 150; HBE, human bronchial epithelial; H₂S, hydrogen sulfide; TGF-β1, transforming growth factor-β1; PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1α; LC3, light chain 3; ERK, extracellular signal-regulated kinase

ISSN: 1465-993X