Skip to main content
Fig. 1 | Respiratory Research

Fig. 1

From: Roles of sirtuin family members in chronic obstructive pulmonary disease

Fig. 1

Members of the sirtuin family are involved in the regulation of COPD. Briefly, SIRT1, SIRT2, SIRT6, and SIRT7 are localized in the nucleus. SIRT1, SIRT2 and SIRT6 inhibit the NF-κB signaling pathway to improve inflammatory response, SIRT1 and SIRT6 inhibit the TGF-β1 signaling pathway to alleviate EMT. SIRT1 can also regulate autophagy through the PI3K/mTOR signaling pathway. SIRT3, SIRT4, and SIRT5 are located in the cytoplasm. SIRT3 and SIRT1 improve oxidative stress response by interacting with PGC-1α, SIRT4 inhibits IκBα to improve pulmonary endothelial dysfunction, and SIRT5 and SIRT1 promote FOXO3a deacetylation to regulate apoptosis and autophagy

Back to article page