Fig. 1From: Roles of sirtuin family members in chronic obstructive pulmonary diseaseMembers of the sirtuin family are involved in the regulation of COPD. Briefly, SIRT1, SIRT2, SIRT6, and SIRT7 are localized in the nucleus. SIRT1, SIRT2 and SIRT6 inhibit the NF-κB signaling pathway to improve inflammatory response, SIRT1 and SIRT6 inhibit the TGF-β1 signaling pathway to alleviate EMT. SIRT1 can also regulate autophagy through the PI3K/mTOR signaling pathway. SIRT3, SIRT4, and SIRT5 are located in the cytoplasm. SIRT3 and SIRT1 improve oxidative stress response by interacting with PGC-1α, SIRT4 inhibits IκBα to improve pulmonary endothelial dysfunction, and SIRT5 and SIRT1 promote FOXO3a deacetylation to regulate apoptosis and autophagyBack to article page