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Fig. 3 | Respiratory Research

Fig. 3

From: LPA1 antagonist BMS-986020 changes collagen dynamics and exerts antifibrotic effects in vitro and in patients with idiopathic pulmonary fibrosis

Fig. 3

Heatmaps (A, B) and scatterplots and linear regression of ECM-neoepitope biomarker levels and pulmonary measures (C–E). A Heatmap of pairwise Spearman correlation of baseline ECM-neoepitope biomarker levels with baseline FVC and fibrosis measurements. B Heatmap of pairwise Spearman correlation of Week 26 ECM-neoepitope biomarker CFB with FVC and fibrosis CFB. Scatterplots and linear regression of baseline PRO-C4 and C6M levels by baseline whole lung QLF (C, D) and Week 26 CFB in C3M by Week 26 CFB in FVC, colored by treatment arm (E). *P < 0.05. CFB change from baseline; BID twice daily; FVC forced vital capacity; QD once daily; QLF quantitative lung fibrosis. ECM-neoepitope biomarker abbreviations are defined in Table 1

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Respiratory Research

ISSN: 1465-993X

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