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Table 1 Characteristics of AE-RA-ILD and AE-IPF patients

From: Acute exacerbation of rheumatoid arthritis-associated interstitial lung disease: mortality and its prediction model

 

AE-RA-ILD

N = 58

AE-IPF

N = 96

P-value

Age, yearsa

73 (68–80)

74 (69–79)

0.8244

Sex, male

35 (60.3)

81 (84.4)

0.0011

Smoking, evera

39 (67.2)

80 (83.3)

0.0286

Baseline %FVCb

81.7 (66.2–90.6)

69 (54.2–84.4)

0.0059

Baseline %DLCOb, c

59.9 (47.1–75.4)

58.5 (43.0–78.5)

0.9939

P/F at AE, Torra

220 (163–285)

223 (163–276)

0.7883

C-reactive protein, mg/dLa

9.4 (5.7–14.9)

11.4 (8.3–17.2)

0.3654

Rheumatoid factor, U/mLa

116 (37–322)

ACPA, positiveb, d

41 (89.1)

KL-6, U/mLa

1042 (739–1559)

1530 (973–2456)

0.0013

Baseline HRCT patternb

< 0.0001

 UIP

34 (58.6)

85 (88.5)

 

 Probable UIP

10 (17.2)

11 (11.5)

 

 Indeterminate for UIP

3 (5.2)

0 (0)

 

 Alternative

11 (19.0)

0 (0)

 

Infection-triggered AEe

5 (8.6)

12 (12.5)

0.5983

Treatment for AE

 Methylprednisolone pulse

58 (100)

96 (100)

1.0000

 Prednisolone

58 (100)

96 (100)

1.0000

 Immunosuppressant

31 (53.5)

34 (35.4)

0.0304

  Intravenous cyclophosphamide

19 (32.8)

32 (33.3)

1.0000

  Calcineurin inhibitor

13 (22.4)

2 (2.1)

< 0.0001

Post-AE observation period, day

121 (22–755)

236 (28–477)

0.8741

Mortality within 90 days after AE onset

28 (48.3)

34 (35.4)

0.1292

Mortality during study period

43 (74.1)

82 (85.4)

0.0925

 Respiratory condition-related mortality

37 (63.8)

71 (74.0)

0.2058

  1. Data presented as median (interquartile range) or as number (%)
  2. AE acute exacerbation, RA rheumatoid arthritis, ILD interstitial lung disease, IPF idiopathic pulmonary fibrosis, HRCT high-resolution computed tomography, UIP usual interstitial pneumonia, %FVC percent predicted forced vital capacity, %DLCO percent predicted diffusing capacity of the lung for carbon monoxide, P/F PaO2/FiO2 ratio, ACPA anti-cyclic citrullinated peptide antibody, KL-6 Krebs von den Lungen-6
  3. aAt AE onset
  4. bWithin 12 months before AE
  5. cRA, n = 34; IPF, n = 62
  6. dn = 46
  7. eDue to an apparent infection with an identifiable cause that occurred within 1 month before AE onset