Identification of factors impairing exercise capacity after severe COVID-19 pulmonary infection: a 3-month follow-up of prospective COVulnerability cohort

Table 3 Multivariable analysis to identify the factors associated with VO₂peak

	Unadjusted analyses			Multivariable analysis
Parameters	Correlation coefficient, r	Unadjusted linear regression coefficient (CI95%)	p-Value	Adjusted linear regression coefficient (CI95%)	p-Value
Age, years	0.18	0.004 (0.000;0.008)	0.070	0.01 (0.003–0.012)	0.001
Body mass index, kg/m²	0.33	0.016 (0.007;0.025)	0.0006	(–)
Pulmonary function
FVC, % predicted	0.52	0.007 (0.005;0.009)	< 0.0001	(–)
FEV1, % predicted	0.51	0.007 (0.005;0.009)	< 0.0001	(–)
TLC, % predicted	0.52	0.009 (0.006;0.012)	< 0.0001	0.01 (0.003–0.01)	0.0004
DLCO, % predicted	0.38	0.005 (0.003;0.007)	< 0.0001	(–)
Skeletal muscle mass and function
ASMMI, kg/m²	0.34	0.072 (0.032;0.113)	0.0006	0.09 (0.05–0.12)	< 0.0001
Grip test, kg	0.25	0.006 (0.001;0.011)	0.027	(–)
Transthoracic echocardiography
LVMi, g/m²	− 0.29	− 0.003 (− 0.005; − 0.001)	0.009	(–)
PAcT, ms	0.35	0.003 (0.001;0.005)	0.017	(–)

Bold type represents statistical significance. DLCO diffusing capacity of the lungs for carbon monoxide, FEV1 forced expiratory volume in the first second, FVC forced vital capacity, KCO diffusion coefficient, TCL total lung capacity, PaO2 partial pressure of oxygen assessed by blood gas analysis, PaCO2 partial pressure of carbon dioxide assessed by blood gas analysis, ASMMI appendicular skeletal muscle mass index, PAcT pulmonary acceleration time, CO cardiac output, LVMi left ventricular mass index, LAVi left atrial volume index, RVEDs right ventricular ejection delays, TAPSE tricuspid annular plane systolic excursion, TRV tricuspid regurgitation velocity, PAP pulmonary artery pressure, RA right atrium

ISSN: 1465-993X