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Table 2 Plasma lipids and liver parameters according to α1-antitrypsin genotype

From: Severe α1-antitrypsin deficiency associated with lower blood pressure and reduced risk of ischemic heart disease: a cohort study of 91,540 individuals and a meta-analysis

Genotype

MM (n = 91,148)

SZ (n = 207)

ZZ (n = 185)

Plasma lipids

   

 Total cholesterol, mmol/L

5.6 ± 1.1

5.6 ± 1.0

5.5 ± 1.0

 HDL cholesterol, mmol/L

1.6 (1.2–1.9)

1.5 (1.2–1.9)

1.6 (1.3–2.0)

 LDL cholesterol, mmol/L

3.2 ± 1.0

3.3 ± 0.9

3.2 ± 0.8

 Remnant cholesterol, mmol/L

0.6 (0.4–0.9)

0.7 (0.5–0.9)

0.5 (0.4–0.7)

 Triglycerides, mmol/L

1.4 (1.0–2.1)

1.4 (1.0–2.1)

1.1 (0.8–1.6)

 Lipoprotein(a), mg/dL

11.7 (5.9–31.0)

12.1 (6.3–25.8)

13.5 (6.0–30.4)

Plasma liver parameters

   

 ALAT, U/L

23.6 ± 16.6

27.0 ± 14.8

28.3 ± 16.4

 Bilirubin, µmol/L

10 (8–13)

11 (8–13)

11 (9–14)

 Alkaline phosphatases, U/L

82.2 ± 25.8

89.7 ± 26.9

86.6 ± 25.9*

 Lactate dehydrogenase U/L

158 ± 33.8

158 ± 39.4

163 ± 36.0

  1. Values presented as mean ± SD or median (25 and 75 percentiles). *P value< 0.05, P value< 0.01, and P value< 0.001 versus MM on Student’s t-test. ALAT alanine aminotransferase