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Table 1 Demographic, clinical, blood, and imaging characteristics of participants according to the presence of airflow limitation compatible with COPD

From: Determinants of blood eosinophil levels in the general population and patients with COPD: a population-based, epidemiological study

 

COPD (n = 326)

Non-COPD (n = 399)

All (n = 725)

P value

Demographic

 Age, years

66.9 (10.5)

60.1 (10.5)

63.2 (11.0)

< 0.0001

 Sex, male, %

182 (55.8%)

154 (38.6%)

336 (46.3%)

< 0.0001

 BMI

27.1 (4.4)

27.1 (4.8)

27.1 (4.6)

0.986

 Smoker

114 (35.0%)

86 (21.6%)

200 (27.6%)

< 0.0001

 Former smoker

151 (46.3%)

152 (38.1%)

303 (41.8%)

 

 Never smoker

61 (18.7%)

161 (40.4%)

222 (30.6%)

 

Clinical

 Asthma diagnosis

42 (12.9%)

32 (8.0%)

74 (10.2%)

0.031

 CAT

9.2 (6.9)

7.0 (5.9)

8.0 (6.5)

< 0.0001

 FEV1, L

2.2 (0.7)

2.9 (0.7)

2.6 (0.8)

< 0.0001

 FEV1, %

82.0 (18.7)

104.6 (14.6)

94.4 (20.0)

< 0.0001

 DLCO, %

89.9 (23.1)

98.8 (18.4)

94.8 (21.1)

< 0.0001

 FEV1/FVC

62.0 (8.4)

79.8 (5.1)

71.8 (11.1)

< 0.0001

 6 MWD, m

478 (108)

518 (98)

501 (105)

 < 0.0001

 YPAS, score

45.7 (23.1)

48.4 (21.6)

47.2 (22.3)

0.111

 Exacerbations last year

0.27 (0.82)

0.05 (0.27)

0.14 (0.60)

< 0.0001

 Treatment with ICS

61 (18.7%)

16 (4.0%)

77 (10.6%)

< 0.0001

Blood

 Erythrocyte, cells/µl

4.95 (0.52)

4.92 (0.44)

4.93 (0.47)

0.796

 Leukocyte, cells/µl

7273 (2194)

6746 (1838)

6983 (2022)

0.0005

 Neutrophils, cells/µl

4284 (1603)

3925 (1426)

4086 (1518)

0.001

 Neutrophils, %

58.5 (9.2)

57.3 (8.3)

57.9 (8.8)

0.068

 Eosinophils, cells/µl

192 (125)

160 (114)

175 (120)

0.0003

 Eosinophils < 100 cell/μL

67 (20.6%)

131 (32.8%)

198 (27.3%)

0.0002

 Eosinophils > 300 cells/μL

52 (16.0%)

46 (11.5%)

98 (13.5%)

0.080

 Eosinophils, %

2.8 (1.8)

2.4 (1.6)

2.6 (1.7)

0.008

 Platelets, cells/µl

233 (58)

241 (62)

238 (61)

0.070

 Fibrinogen (g/L)

3.9 (0.9)

3.8 (0.9)

3.8 (0.9)

0.208

 CRP (mg/dL)

2.0 (4.1)

1.5 (2.8)

1.7 (3.4)

0.0514

Imaging

 Emphysema, %

10.0 (11.9)

4.7 (7.5)

7.0 (10.0)

< 0.0001

 Airway wall area, % (Primary bronchi)

18.4 (2.9)

16.9 (3.4)

17.6 (3.3)

< 0.0001

 Airway wall area, % (Secondary bronchi)

27.5 (5.7)

24.6 (5.6)

25.9 (5.8)

< 0.0001

  1. BMI body mass index, CAT COPD assessment test, FEV1 forced expiratory volume in the first second, FVC forced vital capacity, DLCO diffusion capacity of the lung for carbon monoxide, 6MWD 6-min walk distance, YPAS Yale Physical Activity Questionnaire, CRP C-reactive protein
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Respiratory Research

ISSN: 1465-993X

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