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Table 1 Demographic, clinical, blood, and imaging characteristics of participants according to the presence of airflow limitation compatible with COPD

From: Determinants of blood eosinophil levels in the general population and patients with COPD: a population-based, epidemiological study

  COPD (n = 326) Non-COPD (n = 399) All (n = 725) P value
Demographic
 Age, years 66.9 (10.5) 60.1 (10.5) 63.2 (11.0) < 0.0001
 Sex, male, % 182 (55.8%) 154 (38.6%) 336 (46.3%) < 0.0001
 BMI 27.1 (4.4) 27.1 (4.8) 27.1 (4.6) 0.986
 Smoker 114 (35.0%) 86 (21.6%) 200 (27.6%) < 0.0001
 Former smoker 151 (46.3%) 152 (38.1%) 303 (41.8%)  
 Never smoker 61 (18.7%) 161 (40.4%) 222 (30.6%)  
Clinical
 Asthma diagnosis 42 (12.9%) 32 (8.0%) 74 (10.2%) 0.031
 CAT 9.2 (6.9) 7.0 (5.9) 8.0 (6.5) < 0.0001
 FEV1, L 2.2 (0.7) 2.9 (0.7) 2.6 (0.8) < 0.0001
 FEV1, % 82.0 (18.7) 104.6 (14.6) 94.4 (20.0) < 0.0001
 DLCO, % 89.9 (23.1) 98.8 (18.4) 94.8 (21.1) < 0.0001
 FEV1/FVC 62.0 (8.4) 79.8 (5.1) 71.8 (11.1) < 0.0001
 6 MWD, m 478 (108) 518 (98) 501 (105)  < 0.0001
 YPAS, score 45.7 (23.1) 48.4 (21.6) 47.2 (22.3) 0.111
 Exacerbations last year 0.27 (0.82) 0.05 (0.27) 0.14 (0.60) < 0.0001
 Treatment with ICS 61 (18.7%) 16 (4.0%) 77 (10.6%) < 0.0001
Blood
 Erythrocyte, cells/µl 4.95 (0.52) 4.92 (0.44) 4.93 (0.47) 0.796
 Leukocyte, cells/µl 7273 (2194) 6746 (1838) 6983 (2022) 0.0005
 Neutrophils, cells/µl 4284 (1603) 3925 (1426) 4086 (1518) 0.001
 Neutrophils, % 58.5 (9.2) 57.3 (8.3) 57.9 (8.8) 0.068
 Eosinophils, cells/µl 192 (125) 160 (114) 175 (120) 0.0003
 Eosinophils < 100 cell/μL 67 (20.6%) 131 (32.8%) 198 (27.3%) 0.0002
 Eosinophils > 300 cells/μL 52 (16.0%) 46 (11.5%) 98 (13.5%) 0.080
 Eosinophils, % 2.8 (1.8) 2.4 (1.6) 2.6 (1.7) 0.008
 Platelets, cells/µl 233 (58) 241 (62) 238 (61) 0.070
 Fibrinogen (g/L) 3.9 (0.9) 3.8 (0.9) 3.8 (0.9) 0.208
 CRP (mg/dL) 2.0 (4.1) 1.5 (2.8) 1.7 (3.4) 0.0514
Imaging
 Emphysema, % 10.0 (11.9) 4.7 (7.5) 7.0 (10.0) < 0.0001
 Airway wall area, % (Primary bronchi) 18.4 (2.9) 16.9 (3.4) 17.6 (3.3) < 0.0001
 Airway wall area, % (Secondary bronchi) 27.5 (5.7) 24.6 (5.6) 25.9 (5.8) < 0.0001
  1. BMI body mass index, CAT COPD assessment test, FEV1 forced expiratory volume in the first second, FVC forced vital capacity, DLCO diffusion capacity of the lung for carbon monoxide, 6MWD 6-min walk distance, YPAS Yale Physical Activity Questionnaire, CRP C-reactive protein