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Table 2 List of genes for each module

From: Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease

Genes

Name of module the interactors are member of

Name of module the interactors connect to

AGTR1, AKAP5, ARNT2, JAK2, KIF11, MAPK8, MKNK1, MTA1, NRG2, PRKAR1B, PTPRK, SPI1, SPRY2, TRIP6

Fetal lung methylation module

COPD methylation module

MAPK8, MKNK1, NRG2, AGTR1, CRADD, BRCA1, VAV1, JAK2, MTA1, PRKAR1B, UBE2I, NUP214, GRM1, DLGAP2, EEF1A2, AFAP1, MVP, TRIP6, PTPRK, EPS15, KIAA1949, BCL11A, KIFC1

Fetal lung methylation module

COPD expression module

POLR3K, VPS52, CBR1, BCL11B, OBSCN, RDH10, AP2A2, GAK, ZFPM1, ZNRD1, NUP155, IL1RN, GLE1, DNMT3B, POR, CYP2S1, TRIP13, CNRIP1, CCR5, MDK

Fetal lung methylation module

No module

ATF7, CAMK2A, CEBPA, CHRM1, DAPK1, DAPK2, EBF1, EGFR, ERBB2, ETS1, MAP3K6, PRKCH, PXN, RUNX1T1, ULK2

COPD methylation module

Fetal lung methylation module

CEBPA, CHRM1, DAPK1, EBF1, EGFR, ERBB2, ETS1, MAP3K6, PRKCH, PXN, ULK2, EPHB2, ITGA9, KALRN, MCF2L, PARVA, PLXNB1, RAB27A, RAB34, RAB8B, RASL12, RHOB, SORBS1

COPD methylation module

COPD expression module

TRIM71, EBF3, DICER1, MYRIP, TLX1, ARHGEF17, MATN1, LAMB2, ITGB4, RNASE1

COPD methylation module

No module

BLK, RASD2, CDC42, RAP1B, EDNRB, HNRNPA1, TPM3, EEF1B2, EDN1, VEGFA, BCL2, CIT, HMGB1, SPCS2, RAC1, ABL1, HSP90AA1, OAZ1, PGGT1B, CD24, ACTA1, LIMS1, PDPK1

COPD expression module

COPD methylation module

CDC42, NQO1, RAP1B, CD79A, ABL1, EDN1, HSP90AA1, PPP3CB, BCL2, VEGFA, ACTA1, SUMO2, PPIA, PDPK1, RAC1, HSPA5, DLG2, EEF1B2, NNT, FCRL2, UBQLN1, BLK, POU2AF1, BCL11A

COPD expression module

Fetal lung methylation module

TMEM176B, S100A10, BCLAF1, SEPT6, SYNE1, PGK1, HSPA13, CCT6P1, RBM33, MS4A1, PPIB, SKP2, ELMO1, SLC25A12, GAS2, PPIL3, LOC440563, FCGR2B, FNTA, TAGLN2, PTCD1, PLA2G7, VDAC1, BPGM, GAD1, DNAJB14, SERPINE2, PI4K2B, RPSA

COPD expression module

No module

  1. The second column gives the name of the module the genes are member of, whereas the third column gives the name of the module the genes connect to. If the third column is “No module” then those genes are not interactors