Fig. 2

The subnetwork of the connected component in Fig. 1e given by all genes which can be associated with COPD. Using the subnetwork given by the three modules (Fig. 1e) we only kept the genes, and their interactions, which can be associated to COPD by DisGeNet or GWAS studies. Pink genes are members of the fetal lung methylation module, yellow genes are members of the COPD methylation disease module and turquoise genes are members of the COPD expression disease module. The blue vs. red, edges represent physical vs. functional, interactions, whereas green edges represent both