Fig. 3

Functional gene clusters and the lung volume response to MV. Principal component analysis (PCA) was used to group genes in each functional category. The Pearson correlation coefficient was used measure the strength of the linear association between the generated PCA score for each category and lung volume (nVt and nEEV) in the MV group (n = 15) (a). PCA scores for the selected gene sets were compared amongst the three regions (R1, L2 and R4) after MV (b) (n = 6 per group; Values are mean + SD). ^* p < 0.05, ^** p < 0.01 (compared to R4 for graph B). nVt: normalized tidal volume; nEEV: normalized EEV