Fig. 6
From: Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema
Comparison of gene profiles between control and nicotine-exposed mice with and without elastase instillation at ped21. Genetic profile of 4 different groups, namely control-saline (C-S), control-elastase (C-E), nicotine-saline (N-S), nicotine-elastase (N-E) was compared (A). Three to 5 different animals were used in each group. Nicotine exposure resulted in differential expression of 75 genes (46 upregulated and 29 downregulated) in elastase samples (A bottom arrow) and only 2 genes in saline samples (A upper arrow). Pathway analysis was performed with upregulated (B) and downregulated genes (C) from the analysis N-E vs. C-E and top 10 (or less) pathways with a -log(pValue) of 3 or more are shown