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Fig. 3 | Respiratory Research

Fig. 3

From: Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema

Fig. 3

Comparison of gene profiles between control and nicotine-exposed mice with or without elastase instillation at ped3. Lung mRNA was collected at ped3 from 4 different groups, namely control-saline (C-S), control-elastase (C-E), nicotine-saline (N-S), nicotine-elastase (N-E), and sequenced. Three different animals were used in all the groups except in N-E, where we used 5 animals. The data are represented by multidimensional scaling (MDS) (A). The distances between the dots for the same color group represent the differences of expression between samples (based on fold changes (FC) between samples). Differential gene expression with significance higher than 0.05 and FC of 2 or higher, of N-S vs. C-S (upper arrow) and N-E vs. C-E (lower arrow) is shown in B. Results of pathway analysis include only pathways with -log(pValue) of 3 or more. Analysis was performed on 219 upregulated genes in N-S vs. C-S, and on 109 downregulated genes in N-E vs. C-E. Top 10 pathways are shown for the upregulated genes (C), as well as the 4 identified pathways for the downregulated genes (D)

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