Transcriptomic analysis and validation reveal the pathogenesis and a novel biomarker of acute exacerbation of chronic obstructive pulmonary disease

Table 1 Demographic of included subjects used for RNA-seq

	Control	Stable COPD	AECOPD
Samples, N	5	4	4
Age, years	76.80 ± 8.66	68.50 ± 5.41	74.00 ± 3.39
Sex	4 male, 1 female	4 male	3 male, 1 female
Smoking status	1 current, 2 former, 2 never	2 current, 1 former, 1 never	1 current, 2 former, 1 never
BMI, kg/m²	23.99 ± 2.95	23.54 ± 2.52	22.85 ± 3.90
FEV₁, %Predicted	NA	61.58 ± 11.19	45.23 ± 20.97
FEV₁/FVC ratio, %	NA	57.46 ± 13.47	49.10 ± 15.35
Basic disease	Hypertension, diabetes	Hypertension, coronary heart disease	Hypertension, coronary heart disease

COPD chronic obstructive pulmonary disease, AECOPD acute exacerbation of chronic obstructive pulmonary disease, BMI body mass index, NA not applicable

ISSN: 1465-993X