Fig. 2
From: Effect of indacaterol/glycopyrronium on ventilation and perfusion in COPD: a randomized trial
Distribution of 3He within the lung by MRI: quantitative percentage ventilated lung volume assessment for sample Patient 1 (additional images and video are available in Additional file 1: Fig. S1). Shown are example 3He MRI image segmentations of the lungs acquired during the placebo and treatment periods from a patient demonstrating the effect of IND/GLY compared with placebo. Upper panels: Source images showing the distribution of hyperpolarized 3He gas within the lung. 2D coronal slices from back to front (upper left to lower right) were acquired for volumetric assessment after 7 days of placebo and IND/GLY treatment in the respective treatment periods. Center panels: Image segmentations with ventilated lung shown in blue and unventilated lung shown in brown (2D slices). Lower panels: 3D volume rendering of the image segmentations. IND/GLY indacaterol/glycopyrronium, MRI magnetic resonance imaging