Fig. 5

NIF promotes the resolution of inflammation and improves survival in BLM-induced lung fibrosis. a Experimental design of NIF for the treatment of fibrosis after BLM-induced lung injury in mice. b Survival curves of mice: n = 4 (Sham), n = 9 (Vehicle), n = 8 (25 mg/kg, 50 mg/kg). c Hydroxyproline content in lung homogenates from the groups of mice depicted in a. Statistical significance was assessed using Student’s t test. d–h Analysis of IL-2, IL-4, IL-10, IL-17A, and TNF-α levels in the serum of control and BLM-treated mice in the presence of vehicle or NIF. Statistical significance was assessed using one-way ANOVA followed by Tukey’s test. All data are shown as the mean ± SD; n = 3–5; *P < 0.05, **P < 0.01 vs. Sham; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. Vehicle