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Table 2 Examinations and treatments during hospitalization of the study patients according to status of coronary artery disease and sex

From: Clinical and economic burden of comorbid coronary artery disease in patients with acute exacerbation of chronic obstructive pulmonary disease: sex differences in a nationwide cohort study

Variables, N (missing)a

CAD (n = 664)

No CAD (n = 3242)

P-value

Men

Women

CAD (n = 500)

No CAD (n = 2564)

P-value

CAD (n = 164)

No CAD (n = 678)

P-value

Heart rate (beats per min), 4

84.0 (20.0)

87.0 (19.0)

< 0.001

84.0 (22.0)

87.0 (20.0)

 < 0.001

85.0 (18.0)

87.0 (18.0)

0.131

Respiratory rate (breaths per min), 12

20.0 (2.0)

20.0 (2.0)

0.595

20.0 (2.0)

20.0 (2.0)

0.705

20.0 (2.0)

20.0 (2.0)

0.634

Blood gasb, 1983

 pH

7.42 (0.05)

7.41 (0.05)

0.430

7.41 (0.05)

7.41 (0.05)

0.941

7.42 (0.04)

7.42 (0.05)

0.326

 PaO2 (mmHg)

71.0 (19.0)

70.0 (19.0)

0.428

70.9 (19.0)

71.0 (19.0)

0.511

71.0 (19.0)

68.0 (18.0)

0.445

 PaCO2 (mmHg)

41.2 (9.0)

41.4 (10.0)

0.426

41.0 (9.0)

41.4 (10.0)

0.290

42.0 (10.0)

41.8 (9.0)

0.929

Blood routine, 48

 WBCs (× 109/L)

7.20 (3.83)

7.21 (3.75)

0.451

7.38 (3.82)

7.26 (3.84)

0.447

7.01 (3.90)

7.12 (3.54)

0.739

 Neutrophils (%)

70.0 (15.5)

70.1 (17.6)

0.737

71.3 (16.0)

70.3 (17.8)

0.554

68.6 (13.2)

69.5 (16.8)

0.823

 Lymphocytes (%)

19.0 (13.0)

18.7 (14.6)

0.698

18.1 (12.7)

18.2 (14.7)

0.500

21.2 (12.5)

20.9 (14.0)

0.983

 NLR

3.7 (3.7)

3.7 (4.3)

0.744

3.8 (4.1)

3.9 (4.6)

0.545

3.3 (2.8)

3.3 (3.1)

0.900

 Eosinophils (%)

1.6 (2.6)

1.4 (2.8)

0.030

1.6 (2.7)

1.5 (2.9)

0.037

1.4 (2.5)

1.3 (2.5)

0.404

 Red blood cells (× 1012/L)

4.48 (1.00)

4.52 (1.00)

0.063

4.51 (1.00)

4.58 (1.00)

0.033

4.42 (1.00)

4.35 (1.00)

0.538

 Hemoglobins (g/L)

136.0 (22.0)

138.0 (24.0)

0.056

137.0 (22.0)

140.0 (24.0)

0.028

131.0 (19.0)

130.0 (21.0)

0.257

 Platelets (× 109/L)

199.0 (80.0)

208.0 (96.0)

0.127

196.0 (80.5)

204.0 (97.0)

0.116

208.0 (92.5)

219.5 (90.8)

0.501

Blood biochemistry, 127

 ALT (U/L)

16.0 (11.8)

16.6 (12.0)

0.160

17.0 (12.4)

17.0 (12.9)

0.298

15.0 (9.2)

15.0 (11.0)

0.653

 AST (U/L)

19.0 (9.0)

19.5 (9.5)

0.037

19.2 (9.7)

19.7 (9.4)

0.250

17.5 (8.7)

19.0 (10.0)

0.040

 BUN (mmol/L)

5.7 (2.9)

5.4 (2.6)

< 0.001

5.8 (2.9)

5.5 (2.6)

0.001

5.1 (2.6)

4.8 (2.4)

0.029

 Cr (μmol/L)

72.0 (29.3)

70.4 (23.1)

0.002

76.5 (29.8)

73.0 (21.3)

 < 0.001

59.2 (23.0)

58.7 (19.9)

0.675

 Blood glucose (mmol/L), 137

5.6 (1.9)

5.5 (1.8)

0.020

5.7 (2.0)

5.5 (1.9)

0.037

5.6 (1.8)

5.4 (1.7)

0.251

 NT-proBNP (pg/ml), 2997

230.6 (584.0)

113.0 (220.0)

 < 0.001

236.0 (577.0)

111.0 (219.0)

 < 0.001

201.0 (558.0)

119.0 (230.0)

0.187

 CRP (mg/L), 1610

5.0 (12.0)

4.7 (15.0)

0.793

5.0 (15.0)

5.0 (16.0)

0.950

4.3 (9.0)

4.3 (11.0)

0.731

 PCT (ng/ml), 1693

0.06 (0.10)

0.05 (0.08)

0.610

0.06 (0.10)

0.05 (0.08)

0.727

0.05 (0.07)

0.05 (0.07)

0.660

 SABD, 0

472 (71.1%)

2447 (75.5%)

0.019

357 (71.4%)

1941 (75.7%)

0.042

115 (70.1%)

506 (74.6%)

0.277

 LAMA, 0

53 (8.0%)

334 (10.3%)

0.074

44 (8.8%)

271 (10.6%)

0.260

9 (5.5%)

63 (9.3%)

0.123

 LABA, 0

50 (7.5%)

387 (11.9%)

0.001

41 (8.2%)

309 (12.1%)

0.014

9 (5.5%)

78 (11.5%)

0.031

 ICS, 0

71 (10.7%)

441 (13.6%)

0.043

56 (11.2%)

350 (13.7%)

0.149

15 (9.1%)

91 (13.4%)

0.151

 Nebulized corticosteroids, 0

438 (66.0%)

2061 (63.6%)

0.249

324 (64.8%)

1613 (62.9%)

0.447

114 (69.5%)

448 (66.1%)

0.408

 Systemic corticosteroids, 0

180 (27.1%)

1091 (33.7%)

0.001

144 (28.8%)

876 (34.2%)

0.022

36 (22.0%)

215 (31.7%)

0.017

 Antibiotics, 0

577 (86.9%)

2807 (86.6%)

0.851

426 (85.2%)

2208 (86.1%)

0.622

151 (92.1%)

599 (88.3%)

0.209

 ICU admission, 0

13 (2.0%)

29 (0.9%)

0.022

12 (2.4%)

25 (1.0%)

0.013

1 (0.6%)

4 (0.6%)

1.000

  1. Data are presented as n (%) or median (IQR). aThe number of missing values for each variable. bBlood gas was measured under the condition of breathing in room air
  2. CAD coronary artery disease, PaO2 partial pressure of oxygen, PaCO2 partial pressure of carbon dioxide, WBCs white blood cells, NLR neutrophil-to-lymphocyte ratio, ALT alanine aminotransferase, AST aspartate aminotransferase, BUN blood urea nitrogen, Cr creatinine, NT-proBNP N-terminal pro-B-type natriuretic peptide, CRP C-reactive protein, PCT procalcitonin, SABD short-acting bronchodilator, LAMA long-acting muscarinic receptor antagonist, LABA long-acting beta-adrenoceptor agonist, ICS inhaled corticosteroids, ICU intensive care unit