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Fig. 6 | Respiratory Research

Fig. 6

From: Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension

Fig. 6

Intratracheal delivery of AAV1.Notch4 improves pulmonary hemodynamics in the hypoxic PH rats compared with negative controls. A, B The preventive and therapeutic efficacy of AAV1.Notch4 were assessed by right ventricular systolic pressure (RVSP). C Blood pressure (BP) were measured in rats treated with AAV1.Notch4 or AAV1.NC under normoxic or hypoxic condition. D RV hypertrophy was determined by the RV/(LV + S) weight ratio. E RV hypertrophy was determined by the RV/BW ratio. Data were presented as means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. One-way ANOVA followed by Tukey’s correction for post-hoc comparisons were performed for BE. AAV adeno-associated virus, PH pulmonary hypertension, RVSP right ventricular systolic pressure, RV right ventricle, LV left ventricle, BW body weight, S septum, P prevention, T treatment

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