Fig. 1

Notch4 expression is upregulated in lung tissues from patients with HPH and controls. Lung tissues were obtained from patients with confirmed HPH (n = 4) and matched control non-PH patients. (n = 4) A Protein levels of Notch4 in lung tissues from patients with HPH and without PH. B Notch4 (red) and α-SMA (green) immunofluorescence staining in small pulmonary arteries from humans with HPH (P08) or non-PH (P01). Nuclei are counterstained with DAPI (blue). Magnification, × 400; Bar, 20 μm. Data were presented as means ± SD. *P < 0.05. Student’s t-test was performed for A. PH, pulmonary hypertension; HPH, hypoxic pulmonary hypertension; α-SMA, α-smooth muscle actin