NT-pro BNP in AECOPD-PH: old biomarker, new insights-based on a large retrospective case-controlled study

Tian, Fengming; Song, Wen; Wang, Liang; Zeng, Qiang; Zhao, Zhenyu; Feng, Ning; Fan, Jiahui; Wang, Yue; Wang, Jing; Ma, Xiumin

doi:10.1186/s12931-021-01917-3

Respiratory Research

Table 2 Propensity matching scoring model (n = 412)

From: NT-pro BNP in AECOPD-PH: old biomarker, new insights-based on a large retrospective case-controlled study

Variables	P value (Before PSM, n = 412)	P value (After PSM, n = 412)
Variables	P value (Before PSM, n = 412)	Model 1	Model 2	Model 3
Age (year)	0.171	0.061	0.056	0.096
Sex (M/F)	0.001	0.516	0.222	0.058
Systolic blood pressure (mmHg)	0.060	0.006	0.001	0.002
Diastolic blood pressure (mmHg)	0.355	0.654	0.59	0.385
Pulse rate (PR, beats/per minute)	0.498	0.98	0.805	0.843
Body Mass Index (BMI, kg/m²)	0.319	0.921	0.059	0.506
Smoking status (n, SD/%)
Smoking index (SI)	0.028	0.306	0.191	0.105
length of stay (LOS)	0.606	0.191	0.222	0.096
Complications
Diabetes mellitus (DM)	0.354	0.608	0.523	0.791
Coronary atherosclerotic heart disease (CHD)	< 0.001	0.072	0.057	0.136
Hypertension	0.008	0.263	0.185	0.263
History of cerebral infarction	0.004	0.056	0.060	0.089
Procalcitonin (ng/mL)	0.752	0.031	0.03	0.067
C-reactive protein (CRP, mg/L)	0.092	< 0.001	< 0.001	< 0.001
Interleukin 6 (IL-6, pg/mL)	0.700	0.123	0.122	0.122
Hemoglobin (g/L)	0.147	0.31	0.287	0.304
White blood cell count (WBC, × 10⁹/mL)	0.013	0.008	0.002	0.006
Red blood cell count (RBC, × 10¹² /mL)	0.400	0.035	0.03	0.045
Red cell distribution with (RDW, %)	< 0.001	< 0.001	< 0.001	< 0.001
Mean platelet volume (MPV, fL)	0.065	0.938	0.747	0.872
Fibrinogen degradation products (FDP, μg/mL)	0.499	0.522	0.973	0.94
D-Dimer (DD, ng/mL)	0.743	0.133	0.491	0.205
Albumin (ALB, g/L)	0.513	0.553	0.584	0.454
Abnormal albumin globulin ratio (A/G)	0.091	0.215	0.218	0.207
Triglyceride (TG, mmol/L)	0.410	0.941	0.994	0.861
Total cholesterol (TC, mmol/L)	0.842	0.271	0.196	0.233
High density lipoprotein cholesterol (HDL-C, mmol/L)	0.994	0.115	0.102	0.165
Low density lipoprotein cholesterol (LDL-C, mmol/L)	0.841	0.063	0.058	0.052
Total bilirubin (TBIL, μmol/L)	< 0.001	0.028	0.023	0.025
N terminal pro B type natriuretic peptide (NT-proBNP, pg/ml)	< 0.001	< 0.001	< 0.001	< 0.001

Model 1 matched variables; Sex, age and BMI. Model 2 added SI to model 1. Model 3 Added underlying diseases to model 2 (DM, CHD, hypertension, history of cerebral infarction)

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