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Fig. 7 | Respiratory Research

Fig. 7

From: HuR drives lung fibroblast differentiation but not metabolic reprogramming in response to TGF-β and hypoxia

Fig. 7

HuR knock-down attenuates TGF-β1-induced increase of α-SMA and Collagen I in HLFs. a HuR siRNA significantly decreased HuR protein levels. TGF-β1-induced increase in protein levels of α-SMA b and collagen I c were downregulated significantly following HuR knock-down. d There was a trend towards a decrease in FN protein level following HuR siRNA. e HIF-1α was not altered by exposure to hypoxia with or without TGF-β1 at this timepoint in siCtrl cells. There was more HIF-1α in siHuR cells except in response to hypoxia. Values are represented as the mean ± SEM (n = 2–4 independent experiments using cells from 3 separate subjects); *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001

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