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Fig. 3 | Respiratory Research

Fig. 3

From: Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease

Fig. 3

Relationship between hospitalization and DNAmTL age acceleration. a Kaplan–Meier curve for hospitalization and DNAmTL age acceleration. Axis in (a) corresponds to the probability of hospitalization (y-axis) over time (x-axis). The group with the short DNAmTL corresponds to the description “DNAmTL residuals < − 0.12 or 25th percentile” (blue line). DNAmTL residuals (age acceleration) were derived from the regression of DNAmTL on chronological age adjusted for age, sex, body mass index, smoking status and the first five principal components of blood cell proportions. Long DNAmTL corresponds to the description “DNAmTL residuals > 0.13 or 75th percentile” (red line). The description “− 12 = < DNAmTL residuals > = 0.13” (green line) corresponds to the group with an intermediate DNAmTL. The number of patients at risk at each timepoint is provided inside the plots. P-values were generated using a likelihood ratio test (Cox analysis). Boxplots show the DNAmTL age acceleration plotted against hospitalization status (b) and number of hospitalizations (c). P values at the top of (c) correspond to the P-values adjusted for multiple comparison based on the Tukey method. The beginning and the end of the horizontal bars represent the pairwise comparison that corresponds to each P value

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