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Fig. 1 | Respiratory Research

Fig. 1

From: Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease

Fig. 1

Kaplan–Meier curve for exacerbation and DNAmTL age acceleration. Association between the epigenetic measurement of telomere length (DNAmTL) and probability of exacerbation (y-axis) over time (x-axis). a Corresponds to the Kaplan–Meier curve for acute COPD exacerbations (AECOPD) regardless of severity, while (b) and (c) show the probability of mild and moderate to severe AECOPD over time, respectively. The group with short DNAmTL corresponds to the description “DNAmTL residuals < − 0.12 or 25th percentile” (blue line), in which DNAmTL residuals were derived from the regression of DNAmTL on chronological age adjusted for sex, body mass index, smoking status and the first five principal components of blood cell proportions. Long DNAmTL corresponds to the description “DNAmTL residuals > 0.13 or 75th percentile” (red line). The description “−12 = < DNAmTL residuals > = 0.13” (green line) corresponds to the group intermediate DNAmTL. Number of patients at risk at each timepoint are provided inside the plots. P-values were generated from a likelihood ratio test based on the global test (Cox analysis)

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